FRS2 phenylalanine--tRNA ligase subunit alpha [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FRS2
Official Full Name: phenylalanine--tRNA ligase subunit alpha
Primary source: SGD:S000001872
Locus tag: YFL022C
See related: AllianceGenome:SGD:S000001872; FungiDB:YFL022C; VEuPathDB:YFL022C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables aminoacyl-tRNA editing activity. Contributes to phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Located in cytoplasm. Part of phenylalanine-tRNA ligase complex. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FRS2 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (93499..95010, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the mitochondrial protein synthesis machinery, involving MSF1, lacks the tyrosine proofreading activity characteristic of cytosolic translation with FRS2
Title: Loss of editing activity during the evolution of mitochondrial phenylalanyl-tRNA synthetase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA editing activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity, acting on a tRNA	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to phenylalanine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables phenylalanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in phenylalanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phenylalanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of phenylalanine-tRNA ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phenylalanine-tRNA ligase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phenylalanine--tRNA ligase subunit alpha

NP_116631.1

EC 6.1.1.20

Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

93499..95010 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179944.2 → NP_116631.1 TPA: phenylalanine--tRNA ligase subunit alpha [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116631.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTK8, P15625

UniProtKB/TrEMBL

B3LUI8, C8Z7R1, G2WDB9, N1P357

Conserved Domains (1) summary

PTZ00326
Location:1 → 486

PTZ00326; phenylalanyl-tRNA synthetase alpha chain; Provisional