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    COX15 Cox15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX15
    Official Full Name
    Cox15p
    Primary source
    SGD:S000000943
    Locus tag
    YER141W
    See related
    AllianceGenome:SGD:S000000943; FungiDB:YER141W; VEuPathDB:YER141W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Involved in heme A biosynthetic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; and mitochondrial complex IV deficiency nuclear type 6. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COX15 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (453459..454919)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit B1 CTD phosphatase RTR1 Neighboring gene Emp65p Neighboring gene DNA-3-methyladenine glycosylase II Neighboring gene Ddi1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase. Glerum DM, et al. J Biol Chem, 1997 Jul 25. PMID 9228094
    2. Mitochondrial ferredoxin is required for heme A synthesis in Saccharomyces cerevisiae. Barros MH, et al. J Biol Chem, 2002 Mar 22. PMID 11788607
    3. Evidence that the catalytic mechanism of heme a synthase involves the formation of a carbocation stabilized by a conserved glutamate. Rivett ED, et al. Arch Biochem Biophys, 2023 Aug. PMID 37348627, Free PMC Article
    4. Defects in the biosynthesis of mitochondrial heme c and heme a in yeast and mammals. Moraes CT, et al. Biochim Biophys Acta, 2004 Dec 6. PMID 15576047
    5. The biosynthesis of heme O and heme A is not regulated by copper. Morrison MS, et al. Biochemistry, 2005 Sep 20. PMID 16156667

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings reveal that Cox15 not only associates with respiratory supercomplexes, but also interacts with the cytochrome bc 1 dimer even in the absence of cytochrome c oxidase.
      Title: Cox15 interacts with the cytochrome bc(1) dimer within respiratory supercomplexes as well as in the absence of cytochrome c oxidase.
    2. Shy1 does not serve as a mobile heme carrier between the heme a synthase and maturing Cox1 but rather cooperates with Cox15 for heme transfer and insertion in early assembly intermediates of cytochrome c oxidase.
      Title: The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation.
    3. COX10, the physiological partner of COX15, does not share the same regulatory mechanism with COX15
      Title: Regulation of the heme A biosynthetic pathway: differential regulation of heme A synthase and heme O synthase in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme A biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heme A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cox15p
    NP_011068.1
    • Heme a synthase; required for the hydroxylation of heme O to form heme A, an essential prosthetic group for cytochrome c oxidase; oligomerization is required for function

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      453459..454919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179031.1 → NP_011068.1  TPA: Cox15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011068.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM48, P40086
      UniProtKB/TrEMBL
      A6ZR98, B3LRQ4, B5VHR6, C7GQ55, C8Z7G1, G2WD28, N1P5C6
      Conserved Domains (1) summary
      cl19388
      Location:15 → 451
      COX15-CtaA; Cytochrome oxidase assembly protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40086.1

    Gene LinkOut

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