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    MFB1 Mfb1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MFB1
    Official Full Name
    Mfb1p
    Primary source
    SGD:S000002627
    Locus tag
    YDR219C
    See related
    AllianceGenome:SGD:S000002627; FungiDB:YDR219C; VEuPathDB:YDR219C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrion organization. Acts upstream of or within intracellular distribution of mitochondria. Predicted to be located in mitochondrion. Predicted to be part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MFB1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (905455..906852, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene chromatin-binding protein RAD9 Neighboring gene septin SPR28 Neighboring gene Gtb1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for cell polarity in lifespan and mitochondrial quality control in the budding yeast Saccharomyces cerevisiae. Yang EJ, et al. iScience, 2022 Mar 18. PMID 35281729, Free PMC Article
    2. Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast. Dürr M, et al. Mol Biol Cell, 2006 Sep. PMID 16790496, Free PMC Article
    3. Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. Kondo-Okamoto N, et al. EMBO Rep, 2008 Jan. PMID 18007655, Free PMC Article
    4. A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae. Pernice WM, et al. Nat Commun, 2016 Feb 3. PMID 26839174, Free PMC Article
    5. The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast. Kondo-Okamoto N, et al. Mol Biol Cell, 2006 Sep. PMID 16790494, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MFB1 localizes to mitochondria in the mother tip and is required for mitochondrial anchorage there. Deletion of MFB1 results in loss of the mother-tip-localized mitochondrial population, defects in mitochondrial function and premature replicative aging.
      Title: A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae.
    2. Mitochondria-associated F-box proteins Mfb1 and Mdm30 are key components of a complex machinery that regulates mitochondrial dynamics throughout yeast's entire life cycle.
      Title: Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast.
    3. Mfb1p operates in a novel pathway regulating mitochondrial tubular connectivity
      Title: The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular distribution of mitochondria IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular distribution of mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mfb1p
    NP_010505.3
    • Mitochondria-associated F-box protein; tether that anchors higher-functioning mitochondria at the mother cell distal tip throughout the cell cycle and at the bud tip prior to cytokinesis; role in maintenance of normal mitochondrial morphology and quality control; interacts with Skp1p through the F-box motif; asymmetrically localized to the mother cell through the cell cycle with some bud tip localization just before cytokinesis; function regulated by the bud site selection machinery

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      905455..906852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180527.3 → NP_010505.3  TPA: Mfb1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010505.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSK2, Q04922
      UniProtKB/TrEMBL
      A6ZYH4, B3LG67, C7GVD1, G2WAW5, N1PAF7
      Conserved Domains (1) summary
      pfam12937
      Location:17 → 59
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04922.1

    Gene LinkOut

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