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    TRS85 Trs85p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRS85
    Official Full Name
    Trs85p
    Primary source
    SGD:S000002515
    Locus tag
    YDR108W
    See related
    AllianceGenome:SGD:S000002515; FungiDB:YDR108W; VEuPathDB:YDR108W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GSG1; MUM1
    Summary
    Involved in several processes, including Cvt vesicle assembly; endoplasmic reticulum to Golgi vesicle-mediated transport; and macroautophagy. Located in Golgi apparatus; cytoplasmic vesicle; and phagophore assembly site. Part of TRAPPIII protein complex. Orthologous to human TRAPPC8 (trafficking protein particle complex subunit 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRS85 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (671269..673365)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene Tmn2p Neighboring gene putative phosphotransferase Neighboring gene replication fork barrier binding protein FOB1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GSG1, a yeast gene required for sporulation. Kaytor MD, et al. Yeast, 1995 Sep 30. PMID 8619313
    2. Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae. Nazarko TY, et al. Autophagy, 2005 Apr. PMID 16874038, Free PMC Article
    3. Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway. Meiling-Wesse K, et al. J Biol Chem, 2005 Sep 30. PMID 16079147
    4. Regulation of selective autophagy onset by a Ypt/Rab GTPase module. Lipatova Z, et al. Proc Natl Acad Sci U S A, 2012 May 1. PMID 22509044, Free PMC Article
    5. Regulation of ER-phagy by a Ypt/Rab GTPase module. Lipatova Z, et al. Mol Biol Cell, 2013 Oct. PMID 23924895, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRAPPIII(trs85) is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy.
      Title: TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy.
    2. Trs85 and Ypt1 are localized to the preautophagosomal structure in an Atg9-dependent manner.
      Title: Atg9 vesicles recruit vesicle-tethering proteins Trs85 and Ypt1 to the autophagosome formation site.
    3. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy.
      Title: Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy.
    4. Trs85 is required for nonspecific autophagy, pexophagy and the cytoplasm to vacuole targeting pathway.
      Title: Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae.
    5. TRS85 (GSG1)is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway.
      Title: Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cvt vesicle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to phagophore assembly site IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to phagophore assembly site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Trs85p
    NP_010393.3
    • Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      671269..673365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180416.3 → NP_010393.3  TPA: Trs85p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010393.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS94, P46944, Q04563
      UniProtKB/TrEMBL
      B3LGG7, C8Z524
      Conserved Domains (1) summary
      pfam12739
      Location:225 → 666
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46944.2

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