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    RXT3 Rxt3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RXT3
    Official Full Name
    Rxt3p
    Primary source
    SGD:S000002234
    Locus tag
    YDL076C
    See related
    AllianceGenome:SGD:S000002234; FungiDB:YDL076C; VEuPathDB:YDL076C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in negative regulation of transcription by RNA polymerase I. Located in nucleus. Part of Rpd3L complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RXT3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (320668..321552, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase MDH3 Neighboring gene Vam6p Neighboring gene ribosomal 60S subunit protein L31A Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption and functional analysis of six ORFs on chromosome IV: YDL053c, YDL072c, YDL073w, YDL076c, YDL077c and YDL080c. Blasco A, et al. Yeast, 2000 Nov. PMID 11054825
    2. Natural Diversity in Pentose Fermentation Is Explained by Variations in Histone Deacetylases. Tamari Z, et al. Cell Rep, 2016 Jan 26. PMID 26774473
    3. Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics. Sardiu ME, et al. PLoS One, 2009 Oct 6. PMID 19806189, Free PMC Article
    4. Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Patel AB, et al. Nat Commun, 2023 May 27. PMID 37244892, Free PMC Article
    5. Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Carrozza MJ, et al. Biochim Biophys Acta, 2005 Nov 10. PMID 16314178

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L complex HDA PubMed 
    part_of Rpd3L complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L-Expanded complex HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rxt3p
    NP_010207.1
    • Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      320668..321552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180135.1 → NP_010207.1  TPA: Rxt3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010207.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRS3, Q07458
      UniProtKB/TrEMBL
      A6ZXQ2, B3LGX1, B5VFJ2, C7GJN6, C8Z4J4, N1P5R8
      Conserved Domains (1) summary
      pfam08642
      Location:140 → 252
      Rxt3; Histone deacetylation protein Rxt3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07458.1

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