CSM1 Csm1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CSM1
Official Full Name: Csm1p
Primary source: SGD:S000000682
Locus tag: YCR086W
See related: AllianceGenome:SGD:S000000682; FungiDB:YCR086W; VEuPathDB:YCR086W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable microtubule site clamp. Involved in protein localization to nucleolar rDNA repeats; rDNA chromatin condensation; and spindle attachment to meiosis I kinetochore. Located in nuclear envelope and nucleolus. Part of monopolin complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CSM1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (263392..263964)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Csm1 binds two conserved motifs in Dsn1, one (termed Box 1) representing the ancestral, widely conserved monopolin binding motif and a second (termed Box 2-3) with a likely role in enforcing specificity of sister kinetochore crosslinking. We find that Box 1 and Box 2-3 bind the same conserved hydrophobic cavity on Csm1, suggesting competition or handoff between these motifs. More information in the paper.
Title: The molecular basis of monopolin recruitment to the kinetochore.
Binding to Csm1 regulates substrate specificity of the Ulp2 protease.
Title: Binding to small ubiquitin-like modifier and the nucleolar protein Csm1 regulates substrate specificity of the Ulp2 protease.
we demonstrate that interaction of monopolin subunit Csm1 with the N-terminal domain of MIND complex subunit Dsn1, is essential for both the association of monopolin with kinetochores and for monopolar attachment of sister kinetochores during meiosis
Title: Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I.
The Lrs4-Csm1 complex localize to kinetochores during anaphase and is important for ensuring accurate chromosome segregation. (Csm1 protein)
Title: The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation.
Csm1/Lrs4 (Psc1/Mde4) functions as a molecular clamp, crosslinking kinetochore components to enforce sister chromatid co-orientation in S. cerevisiae meiosis I and to suppress merotelic attachment in S. pombe mitosis.
Title: The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables microtubule site clamp	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in homologous chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome segregation	IPI Inferred from Physical Interaction more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nucleolar rDNA repeats	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA chromatin condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle attachment to meiosis I kinetochore	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in chromosome, centromeric core domain	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
part_of monopolin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of monopolin complex	IDA Inferred from Direct Assay more info	PubMed
part_of monopolin complex	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Csm1p

NP_010009.1

Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

263392..263964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178792.1 → NP_010009.1 TPA: Csm1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010009.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR86, P25651

UniProtKB/TrEMBL

A6ZTQ7, B3LUD9, B5VF13, C7GUW3, C8Z4H3, G2WA93, N1P7X7

Conserved Domains (2) summary

pfam18504
Location:1 → 70

Csm1_N; Csm1 N-terminal domain

pfam12539
Location:72 → 165

Csm1; Chromosome segregation protein Csm1/Pcs1