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    ARO4 3-deoxy-7-phosphoheptulonate synthase ARO4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARO4
    Official Full Name
    3-deoxy-7-phosphoheptulonate synthase ARO4
    Primary source
    SGD:S000000453
    Locus tag
    YBR249C
    See related
    AllianceGenome:SGD:S000000453; FungiDB:YBR249C; VEuPathDB:YBR249C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3-deoxy-7-phosphoheptulonate synthase activity. Predicted to be involved in aromatic amino acid family biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARO4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (716882..717994, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene snoRNA-binding rRNA-processing protein ENP1 Neighboring gene imidazoleglycerol-phosphate synthase Neighboring gene Spo23p Neighboring gene mitochondrial 37S ribosomal protein MRPS5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate and metal complexes of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae provide new insights into the catalytic mechanism. König V, et al. J Mol Biol, 2004 Mar 26. PMID 15019786
    2. A mutated ARO4 gene for feedback-resistant DAHP synthase which causes both o-fluoro-DL-phenylalanine resistance and beta-phenethyl-alcohol overproduction in Saccharomyces cerevisiae. Fukuda K, et al. Curr Genet, 1991 Dec. PMID 1723662
    3. The two 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase isoenzymes from Saccharomyces cerevisiae show different kinetic modes of inhibition. Schnappauf G, et al. Arch Microbiol, 1998 Jun. PMID 9575238
    4. Feedback-insensitive mutants of the gene for the tyrosine-inhibited DAHP synthetase in yeast. Meuris P. Genetics, 1974 Apr. PMID 4599255, Free PMC Article
    5. Genetic transformation of industrial yeasts using an amino acid analog resistance gene as a directly selectable marker. Shimura K, et al. Enzyme Microb Technol, 1993 Oct. PMID 7764106

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-deoxy-7-phosphoheptulonate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-deoxy-7-phosphoheptulonate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-deoxy-7-phosphoheptulonate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    3-deoxy-7-phosphoheptulonate synthase ARO4
    NP_009808.1
    • 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      716882..717994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178597.1 → NP_009808.1  TPA: 3-deoxy-7-phosphoheptulonate synthase ARO4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009808.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQP5, P32449
      UniProtKB/TrEMBL
      A6ZLI8, B3LMR3, B5VEJ9, C7GMY2, D3UEZ6, G2W9Q2, N1P8J9
      Conserved Domains (1) summary
      TIGR00034
      Location:21 → 365
      aroFGH; phospho-2-dehydro-3-deoxyheptonate aldolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32449.2

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