ECM31 3-methyl-2-oxobutanoate hydroxymethyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ECM31
Official Full Name: 3-methyl-2-oxobutanoate hydroxymethyltransferase
Primary source: SGD:S000000380
Locus tag: YBR176W
See related: AllianceGenome:SGD:S000000380; FungiDB:YBR176W; VEuPathDB:YBR176W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity. Involved in pantothenate biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ECM31 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (583720..584658)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monocarboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pantothenate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pantothenate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pantothenate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 3-methyl-2-oxobutanoate hydroxymethyltransferase

NP_009735.3

EC 2.1.2.11

Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

583720..584658

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178524.3 → NP_009735.3 TPA: 3-methyl-2-oxobutanoate hydroxymethyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009735.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQH1, P38122

UniProtKB/TrEMBL

C7GUJ0, G2W9H8

Conserved Domains (1) summary

COG0413
Location:25 → 300

PanB; Ketopantoate hydroxymethyltransferase [Coenzyme transport and metabolism]