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    DIG1 Dig1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIG1
    Official Full Name
    Dig1p
    Primary source
    SGD:S000005970
    Locus tag
    YPL049C
    See related
    AllianceGenome:SGD:S000005970; FungiDB:YPL049C; VEuPathDB:YPL049C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RST1
    Summary
    Enables transcription corepressor activity. Involved in cellular response to pheromone; negative regulation of growth of unicellular organism as a thread of attached cells; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of Ste12p-Dig1p-Dig2p complex and Tec1p-Ste12p-Dig1p complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DIG1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (462481..463839, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Arf family GTPase ARL3 Neighboring gene mannosyltransferase complex subunit MNN9 Neighboring gene translation elongation factor EF1B gamma Neighboring gene SAGA histone acetyltransferase complex subunit SGF11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aneuploidy underlies a multicellular phenotypic switch. Tan Z, et al. Proc Natl Acad Sci U S A, 2013 Jul 23. PMID 23812752, Free PMC Article
    2. Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p. Pi H, et al. Mol Cell Biol, 1997 Nov. PMID 9343403, Free PMC Article
    3. Endogenous transcription at the centromere facilitates centromere activity in budding yeast. Ohkuni K, et al. Curr Biol, 2011 Oct 25. PMID 22000103, Free PMC Article
    4. Assigning quantitative function to post-translational modifications reveals multiple sites of phosphorylation that tune yeast pheromone signaling output. Pincus D, et al. PLoS One, 2013. PMID 23554854, Free PMC Article
    5. Identification and characterization of extragenic suppressors of the yeast sec12 ts mutation. Nakano A. J Biochem, 1996 Sep. PMID 8902631

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the transcriptional repressors Dig1 and Dig2 positively affect transcription by stabilizing Ste12
      Title: Positive roles for negative regulators in the mating response of yeast.
    2. Dig1 represses Ste12-dependent transcription at the centromere.
      Title: Endogenous transcription at the centromere facilitates centromere activity in budding yeast.
    3. Dig1 and Dig2 contribute to the retention of phosphorylated Fus3 in the nucleus.
      Title: The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of invasive growth in response to glucose limitation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ste12p-Dig1p-Dig2p complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Tec1p-Ste12p-Dig1p complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dig1p
    NP_015276.1
    • MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG1 has a paralog, DIG2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      462481..463839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183863.1 → NP_015276.1  TPA: Dig1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015276.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3W5, Q03063
      UniProtKB/TrEMBL
      G2WPC9, N1P1R6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03063.1

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