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    ELC1 elongin C [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856061, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ELC1
    Official Full Name
    elongin C
    Primary source
    SGD:S000005967
    Locus tag
    YPL046C
    See related
    AllianceGenome:SGD:S000005967; FungiDB:YPL046C; VEuPathDB:YPL046C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ubiquitin-protein transferase activity. Involved in global genome nucleotide-excision repair and ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex; elongin complex; and nucleotide-excision repair factor 4 complex. Orthologous to human ELOC (elongin C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ELC1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (466644..466943, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene translation elongation factor EF1B gamma Neighboring gene SAGA histone acetyltransferase complex subunit SGF11 Neighboring gene tethering complex subunit VPS16 Neighboring gene mRNA-binding ribosome biosynthesis protein NOP4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C. Botuyan MV, et al. Proc Natl Acad Sci U S A, 1999 Aug 3. PMID 10430890, Free PMC Article
    2. Elongin from Saccharomyces cerevisiae. Koth CM, et al. J Biol Chem, 2000 Apr 14. PMID 10753924
    3. Biophysical characterization of elongin C from Saccharomyces cerevisiae. Buchberger A, et al. Biochemistry, 2000 Sep 12. PMID 10998253
    4. Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide. Botuyan MV, et al. J Mol Biol, 2001 Sep 7. PMID 11545595
    5. Binding to Elongin C inhibits degradation of interacting proteins in yeast. Hyman LE, et al. J Biol Chem, 2002 May 3. PMID 11864988

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-137 was able to promote sensitivity of PC cells to chemotherapy via inhibition of autophagy mediated by ATG5
      Title: Crystal structure of the yeast Rad7-Elc1 complex and assembly of the Rad7-Rad16-Elc1-Cul3 complex.
    2. In contrast to the DNA damage-dependent pathway, Rpb1 degradation of DNA damage-independently stalled RNAPII is independent of the E3 ligase Elc1.
      Title: Degradation of DNA damage-independently stalled RNA polymerase II is independent of the E3 ligase Elc1.
    3. that Elc1 has no function in TCR but plays an important role in GGR. Furthermore, the role of Elc1 in GGR may not be subsidiary to that of Rad7 and Rad16.
      Title: Yeast Elc1 plays an important role in global genomic repair but not in transcription coupled repair.
    4. Elongin A (Ela1) and cullin 3 (Cul3) are required for Pol II polyubiquitylation and degradation in yeast cells and an E3 comprised of elongin C (Elc1), Ela1, Cul3, and the RING finger protein Roc1 (Rbx1) mediates this process.
      Title: ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.
    5. A novel role for the yeast Elc1 protein in mediating Pol II polyubiquitylation and degradation in DNA-damaged yeast cells and propose the involvement of a ubiquitin ligase, of which Elc1 is a component, in this process.
      Title: Requirement of ELC1 for RNA polymerase II polyubiquitylation and degradation in response to DNA damage in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in global genome nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of Cul3-RING ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of nucleotide-excision repair factor 4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    elongin C
    NP_015279.1
    • Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      466644..466943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183860.1 → NP_015279.1  TPA: elongin C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3W8, O13292, Q03071
      UniProtKB/TrEMBL
      A6ZWK2, B3LL21, C7GU08, C8ZIY3, G2WPD2, N1NVZ0
      Conserved Domains (1) summary
      cd18321
      Location:5 → 99
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03071.1

    Gene LinkOut

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