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    DCI1 putative dodecenoyl-CoA isomerase DCI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DCI1
    Official Full Name
    putative dodecenoyl-CoA isomerase DCI1
    Primary source
    SGD:S000005706
    Locus tag
    YOR180C
    See related
    AllianceGenome:SGD:S000005706; FungiDB:YOR180C; VEuPathDB:YOR180C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ECI2
    Summary
    Enables delta(3)-delta(2)-enoyl-CoA isomerase activity. Involved in fatty acid beta-oxidation. Located in peroxisomal matrix. Orthologous to several human genes including CDYL2 (chromodomain Y like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DCI1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (674352..675167, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulator GAC1 Neighboring gene cleavage polyadenylation factor subunit SYC1 Neighboring gene actin-binding protein LAS17 Neighboring gene ribosomal 40S subunit protein S30B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism. Geisbrecht BV, et al. Biochem Biophys Res Commun, 1999 Jun 24. PMID 10381339
    2. Structures of yeast peroxisomal Δ(3),Δ(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole. Onwukwe GU, et al. Acta Crystallogr D Biol Crystallogr, 2015 Nov. PMID 26527136
    3. Alternatives to the isomerase-dependent pathway for the beta-oxidation of oleic acid are dispensable in Saccharomyces cerevisiae. Identification of YOR180c/DCI1 encoding peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase. Gurvitz A, et al. J Biol Chem, 1999 Aug 27. PMID 10455114
    4. Oleate beta-oxidation in yeast involves thioesterase but not Yor180c protein that is not a dienoyl-CoA isomerase. Ntamack AG, et al. Biochim Biophys Acta, 2009 May. PMID 19830908, Free PMC Article
    5. Eci1p uses a PTS1 to enter peroxisomes: either its own or that of a partner, Dci1p. Yang X, et al. Eur J Cell Biol, 2001 Feb. PMID 11302517

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative dodecenoyl-CoA isomerase DCI1
    NP_014823.3
    • Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      674352..675167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183599.3 → NP_014823.3  TPA: putative dodecenoyl-CoA isomerase DCI1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014823.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2N6, Q08558
      UniProtKB/TrEMBL
      A6ZP25, B3LJL1, B5VS65, C7GLR3, C8ZGU1, G2WN53, N1NX35
      Conserved Domains (1) summary
      COG1024
      Location:1 → 264
      CaiD; Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08558.1

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