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    RPL25 ribosomal 60S subunit protein L25 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853993, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL25
    Official Full Name
    ribosomal 60S subunit protein L25
    Primary source
    SGD:S000005487
    Locus tag
    YOL127W
    See related
    AllianceGenome:SGD:S000005487; FungiDB:YOL127W; VEuPathDB:YOL127W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Orthologous to human RPL23A (ribosomal protein L23a). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL25 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    2
    Sequence:
    Chromosome: XV; NC_001147.6 (80348..81190)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Vps68p Neighboring gene serine/threonine protein kinase YGK3 Neighboring gene malate dehydrogenase MDH2 Neighboring gene tRNA:m4X modification enzyme

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and functional analysis of the nuclear localization signals of ribosomal protein L25 from Saccharomyces cerevisiae. Schaap PJ, et al. J Mol Biol, 1991 Sep 5. PMID 1920406
    2. Domain III of Saccharomyces cerevisiae 25 S ribosomal RNA: its role in binding of ribosomal protein L25 and 60 S subunit formation. van Beekvelt CA, et al. J Mol Biol, 2000 Feb 11. PMID 10656814
    3. Mutational analysis of the C-terminal region of Saccharomyces cerevisiae ribosomal protein L25 in vitro and in vivo demonstrates the presence of two distinct functional elements. Kooi EA, et al. J Mol Biol, 1994 Jul 15. PMID 8028007
    4. Structural comparison of yeast ribosomal protein genes. Leer RJ, et al. Nucleic Acids Res, 1984 Sep 11. PMID 6091033, Free PMC Article
    5. Yeast ribosomal protein L25 binds to an evolutionary conserved site on yeast 26S and E. coli 23S rRNA. el-Baradi TT, et al. EMBO J, 1985 Aug. PMID 3905389, Free PMC Article

    See all (171) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rpl25p plays a critical role in the recruitment of SRP to the ribosome
      Title: Access to ribosomal protein Rpl25p by the signal recognition particle is required for efficient cotranslational translocation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L25
    NP_014514.1
    • Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      80348..81190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183381.1 → NP_014514.1  TPA: ribosomal 60S subunit protein L25 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014514.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1U1, P04456
      UniProtKB/TrEMBL
      A6ZN84, B3LIT9, C8ZHI9, G2WMB0, N1P3G5
      Conserved Domains (1) summary
      PTZ00191
      Location:20 → 142
      PTZ00191; 60S ribosomal protein L23a; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04456.4

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