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    TRM11 tRNA (guanine-N2-)-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRM11
    Official Full Name
    tRNA (guanine-N2-)-methyltransferase
    Primary source
    SGD:S000005484
    Locus tag
    YOL124C
    See related
    AllianceGenome:SGD:S000005484; FungiDB:YOL124C; VEuPathDB:YOL124C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA (guanine(10)-N2)-methyltransferase activity. Involved in tRNA methylation. Located in cytoplasm. Part of tRNA (m2G10) methyltransferase complex. Orthologous to human TRMT11 (tRNA methyltransferase 11 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRM11 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (85456..86757, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase MDH2 Neighboring gene tRNA:m4X modification enzyme Neighboring gene Hrp1p Neighboring gene divalent metal ion transporter SMF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Production of yeast (m2G10) methyltransferase (Trm11 and Trm112 complex) in a wheat germ cell-free translation system. Okada K, et al. Nucleic Acids Symp Ser (Oxf), 2009. PMID 19749381
    2. Activation mode of the eukaryotic m2G10 tRNA methyltransferase Trm11 by its partner protein Trm112. Bourgeois G, et al. Nucleic Acids Res, 2017 Feb 28. PMID 27986851, Free PMC Article
    3. Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast. Mazauric MH, et al. J Biol Chem, 2010 Jun 11. PMID 20400505, Free PMC Article
    4. A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Chan CT, et al. PLoS Genet, 2010 Dec 16. PMID 21187895, Free PMC Article
    5. tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Studte P, et al. Mol Microbiol, 2008 Sep. PMID 18657261

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ynr046w eRF1 methyltransferase subunit is shared by the tRNA methyltransferase Trm11p and probably by two other enzymes containing a Rossman fold
      Title: The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(10)-N2)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(10)-N2)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA (m2G10) methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA (guanine-N2-)-methyltransferase
    NP_014517.1
    • Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; contains a THUMP domain and a methyltransferase domain; methyltransferase complex also contains Trm112p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      85456..86757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183378.1 → NP_014517.1  TPA: tRNA (guanine-N2-)-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1U4, Q12463
      UniProtKB/TrEMBL
      A6ZN87, B3LIU2, B5VRD3, C7GV01, C8ZHJ2, N1NWV5
      Conserved Domains (1) summary
      COG1041
      Location:2 → 427
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12463.1

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