U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ATP23 putative metalloprotease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855754, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ATP23
    Official Full Name
    putative metalloprotease
    Primary source
    SGD:S000005303
    Locus tag
    YNR020C
    See related
    AllianceGenome:SGD:S000005303; FungiDB:YNR020C; VEuPathDB:YNR020C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Involved in mitochondrial protein processing and mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial intermembrane space. Orthologous to human ATP23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATP23 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (667410..668222, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Rcf2p Neighboring gene sterol acyltransferase Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein MRPL50

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. T1121G Point Mutation in the Mitochondrial Gene COX1 Suppresses a Null Mutation in ATP23 Required for the Assembly of Yeast Mitochondrial ATP Synthase. Yang G, et al. Int J Mol Sci, 2022 Feb 19. PMID 35216443, Free PMC Article
    2. Atp23p and Atp10p coordinate to regulate the assembly of yeast mitochondrial ATP synthase. Yang G, et al. FASEB J, 2021 Jun. PMID 33956347
    3. Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria. Weckbecker D, et al. EMBO J, 2012 Nov 14. PMID 22990235, Free PMC Article
    4. The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase. Zeng X, et al. Mol Biol Cell, 2007 Feb. PMID 17135290, Free PMC Article
    5. Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1Fo-ATP synthase. Osman C, et al. Mol Biol Cell, 2007 Feb. PMID 17135288, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atp23 was identified as a novel substrate of Mia40. Oxidation of Atp23 is not essential for its import; an Atp23 variant in which all ten cysteine residues were replaced by serine residues still accumulates in mitochondria in a Mia40-dependent manner.
      Title: Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria.
    2. A new metalloprotease encoded by the nuclear ATP23 gene of Saccharomyces cerevisiae essential for expression of mitochondrial ATPase (F(1)-F(O) complex) was identified.
      Title: The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase.
    3. The identification of a conserved metallopeptidase present in the intermembrane space, termed Atp23, which exerts dual activities during the biogenesis of the F(1)F(O)-ATP synthase was descibed.
      Title: Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1Fo-ATP synthase.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative metalloprotease
    NP_014417.3
    • Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      667410..668222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183197.3 → NP_014417.3  TPA: putative metalloprotease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014417.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1P4R1
      Conserved Domains (1) summary
      pfam09768
      Location:91 → 266
      Peptidase_M76; Peptidase M76 family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools