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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855363, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000004932
    Locus tag
    YMR315W
    See related
    AllianceGenome:SGD:S000004932; FungiDB:YMR315W; VEuPathDB:YMR315W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oxidoreductase activity. Involved in NADPH regeneration. Located in cytoplasm and nucleus. Orthologous to human DHDH (dihydrodiol dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (902800..903849)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase Neighboring gene proteasome core particle subunit alpha 6 Neighboring gene uncharacterized protein Neighboring gene Dia1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae YMR315W gene encodes an NADP(H)-specific oxidoreductase regulated by the transcription factor Stb5p in response to NADPH limitation. Hector RE, et al. N Biotechnol, 2009 Oct 31. PMID 19712762
    2. The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes. Schäfer T, et al. EMBO J, 2003 Mar 17. PMID 12628929, Free PMC Article
    3. Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Fillingham J, et al. Mol Cell Biol, 2008 Jul. PMID 18458063, Free PMC Article
    4. Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Hesselberth JR, et al. Genome Biol, 2006. PMID 16606443, Free PMC Article
    5. Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19. Ren L, et al. PLoS One, 2011 Feb 28. PMID 21386897, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YMR315W transcription is regulated by Stb5p in response to diamide induced NADPH depletion.
      Title: The Saccharomyces cerevisiae YMR315W gene encodes an NADP(H)-specific oxidoreductase regulated by the transcription factor Stb5p in response to NADPH limitation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADPH regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADPH regeneration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_014046.1
    • Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains an Stb5p binding site and Stb5p binding is enriched at the promoter; negative regulator of nonselective autophagy; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      902800..903849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182826.1 → NP_014046.1  TPA: uncharacterized protein YMR315W [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014046.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0E2, Q04869
      UniProtKB/TrEMBL
      A6ZN32, B3LMK3, C7GPU8, C8ZFI6, N1NZ88
      Conserved Domains (1) summary
      COG0673
      Location:1 → 347
      MviM; Predicted dehydrogenase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04869.1

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