NDE1 NADH-ubiquinone reductase (H(+)-translocating) NDE1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NDE1
Official Full Name: NADH-ubiquinone reductase (H(+)-translocating) NDE1
Primary source: SGD:S000004753
Locus tag: YMR145C
See related: AllianceGenome:SGD:S000004753; FungiDB:YMR145C; VEuPathDB:YMR145C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NDH1
Summary: Enables NADH dehydrogenase activity. Involved in NADH oxidation; glycolytic fermentation to ethanol; and regulation of apoptotic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NDE1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (554793..556475, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the current investigation the relationship between ROS production and MMP was studied in respiring yeast cells in stationary phase, using diphenyleneiodonium chloride (DPI), an inhibitor of flavin-containing proteins, as well as the mutants deleted for NDE1, NDE2 and NDI1 genes, encoding flavin-containing external and internal NADH dehydrogenases.
Title: The role of flavin-containing enzymes in mitochondrial membrane hyperpolarization and ROS production in respiring Saccharomyces cerevisiae cells under heat-shock conditions.
impairment in the oxidation of cytosolic NADH by Nde1p is deleterious towards mitochondrial biogenesis due to an increase in reactive oxygen species release
Title: nde1 deletion improves mitochondrial DNA maintenance in Saccharomyces cerevisiae coenzyme Q mutants.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NADH dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables NADH dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables NADH:ubiquinone reductase (non-electrogenic) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADH oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in NADH oxidation	IEA Inferred from Electronic Annotation more info
involved_in glycolytic fermentation to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: NADH-ubiquinone reductase (H(+)-translocating) NDE1

NP_013865.1

EC 1.6.5.9

Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

554793..556475 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182647.1 → NP_013865.1 TPA: NADH-ubiquinone reductase (H(+)-translocating) NDE1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013865.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZW7, P40215

UniProtKB/TrEMBL

A6ZMK4, B3LM33, B5VPS1, C7GQ85, C8ZF02, G2WKJ6, N1P0D9

Conserved Domains (1) summary

COG1252
Location:110 → 559

Ndh; NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]