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    Ivd isovaleryl coenzyme A dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 56357, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ivdprovided by MGI
    Official Full Name
    isovaleryl coenzyme A dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:1929242
    See related
    Ensembl:ENSMUSG00000027332 AllianceGenome:MGI:1929242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300016K07Rik; 6720455E18Rik
    Summary
    Predicted to enable 3-methylbutanoyl-CoA dehydrogenase activity and identical protein binding activity. Predicted to be involved in L-leucine catabolic process and fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; ear; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 99.3), heart adult (RPKM 88.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ivd in Genome Data Viewer
    Location:
    2 E5; 2 59.64 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118692475..118713388)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118861959..118882909)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 38629 Neighboring gene kinetochore-localized astrin/SPAG5 binding Neighboring gene predicted gene, 39913 Neighboring gene STARR-positive B cell enhancer ABC_E2638 Neighboring gene STARR-positive B cell enhancer ABC_E4491 Neighboring gene STARR-positive B cell enhancer ABC_E9528 Neighboring gene predicted gene, 32798 Neighboring gene predicted gene, 32957 Neighboring gene bromo adjacent homology domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of genomic and cDNA for mouse isovaleryl-CoA dehydrogenase (IVD) and evolutionary comparison to other known IVDs. Willard JM, et al. Gene, 2001 May 30. PMID 11404023
    2. Leucine catabolism during the differentiation of 3T3-L1 cells. Expression of a mitochondrial enzyme system. Frerman FE, et al. J Biol Chem, 1983 Jun 10. PMID 6304077
    3. Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. Peng MZ, et al. Cell Mol Life Sci, 2022 Jun 21. PMID 35727412, Free PMC Article
    4. Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Suzuki T, et al. Development, 2019 Feb 15. PMID 30733279, Free PMC Article
    5. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-methylbutanoyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-methylbutanoyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3-methylbutanoyl-CoA dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-leucine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-leucine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-leucine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in branched-chain amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in branched-chain amino acid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    isovaleryl-CoA dehydrogenase, mitochondrial
    Names
    butyryl-CoA dehydrogenase
    NP_001403148.1
    NP_001403149.1
    NP_062800.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416219.1 → NP_001403148.1  isovaleryl-CoA dehydrogenase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772255

    2. NM_001416220.1 → NP_001403149.1  isovaleryl-CoA dehydrogenase, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772255

    3. NM_019826.5 → NP_062800.1  isovaleryl-CoA dehydrogenase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_062800.1

      Status: VALIDATED

      Source sequence(s)
      AL772255
      Consensus CDS
      CCDS16586.1
      UniProtKB/Swiss-Prot
      Q9CYI3, Q9DBD7, Q9JHI5
      Related
      ENSMUSP00000028807.6, ENSMUST00000028807.6
      Conserved Domains (2) summary
      cd01156
      Location:42 → 421
      IVD; Isovaleryl-CoA dehydrogenase
      PLN02519
      Location:43 → 417
      PLN02519; isovaleryl-CoA dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      118692475..118713388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHI5.1 GenPept UniProtKB/Swiss-Prot:Q9JHI5

    Gene LinkOut

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