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    Sst somatostatin [ Mus musculus (house mouse) ]

    Gene ID: 20604, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Sstprovided by MGI
    Official Full Name
    somatostatinprovided by MGI
    Primary source
    MGI:MGI:98326
    See related
    Ensembl:ENSMUSG00000004366 AllianceGenome:MGI:98326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SS; SOM; SRIF; Smst
    Summary
    Enables receptor ligand activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels and somatostatin signaling pathway. Acts upstream of or within regulation of cell migration. Located in extracellular space. Is active in GABA-ergic synapse and cytosol. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Orthologous to human SST (somatostatin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 471.4), cortex adult (RPKM 146.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sst in Genome Data Viewer
    Location:
    16 B1; 16 15.0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (23708327..23710041, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23889573..23891342, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40448 Neighboring gene ATP-binding cassette, sub-family E (OABP), member 1 pseudogene Neighboring gene predicted gene, 31430 Neighboring gene STARR-seq mESC enhancer starr_40450 Neighboring gene STARR-seq mESC enhancer starr_40451 Neighboring gene STARR-seq mESC enhancer starr_40453 Neighboring gene receptor transporter protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr16:23982379-23982679 Neighboring gene STARR-positive B cell enhancer ABC_E10897 Neighboring gene B cell leukemia/lymphoma 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of hippocamposeptal input within the medial septum/diagonal band of Broca. Damborsky JC, et al. Neuropharmacology, 2021 Jun 15. PMID 33933476, Free PMC Article
    2. Somatostatin inhibits oxidative respiration in pancreatic beta-cells. Daunt M, et al. Endocrinology, 2006 Mar. PMID 16357046
    3. Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses. Rafalovich IV, et al. Cell Rep, 2015 Nov 17. PMID 26549446, Free PMC Article
    4. Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics. Adam Y, et al. Nature, 2019 May. PMID 31043747, Free PMC Article
    5. CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. Chou TM, et al. J Headache Pain, 2022 Dec 12. PMID 36510143, Free PMC Article

    See all (1379) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Somatostatin Interneurons Recruit Pre- and Postsynaptic GABAB Receptors in the Adult Mouse Dentate Gyrus.
      Title: Somatostatin Interneurons Recruit Pre- and Postsynaptic GABA(B) Receptors in the Adult Mouse Dentate Gyrus.
    2. Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice.
      Title: Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice.
    3. Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.
      Title: Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.
    4. Activated somatostatin interneurons orchestrate memory microcircuits.
      Title: Activated somatostatin interneurons orchestrate memory microcircuits.
    5. Selective plasticity of fast and slow excitatory synapses on somatostatin interneurons in adult visual cortex.
      Title: Selective plasticity of fast and slow excitatory synapses on somatostatin interneurons in adult visual cortex.
    6. Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
      Title: Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
    7. Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing.
      Title: Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing.
    8. Fear memory recall involves hippocampal somatostatin interneurons.
      Title: Fear memory recall involves hippocampal somatostatin interneurons.
    9. Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons.
      Title: Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons.
    10. Phase- and state-dependent modulation of breathing pattern by preBotzinger complex somatostatin expressing neurons.
      Title: Phase- and state-dependent modulation of breathing pattern by preBötzinger complex somatostatin expressing neurons.
    Submit: New GeneRIF Correction See all GeneRIFs (90)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor ligand activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hyperosmotic response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to acidic pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to amino acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to steroid hormone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in somatostatin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal dense core vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    somatostatin
    Names
    preprosomatostatin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417475.1 → NP_001404404.1  somatostatin precursor

      Status: VALIDATED

      Source sequence(s)
      AC127241
      UniProtKB/Swiss-Prot
      P01167, P60041
      UniProtKB/TrEMBL
      Q545V6

    2. NM_009215.2 → NP_033241.1  somatostatin precursor

      See identical proteins and their annotated locations for NP_033241.1

      Status: VALIDATED

      Source sequence(s)
      AC127241
      Consensus CDS
      CCDS28080.1
      UniProtKB/Swiss-Prot
      P01167, P60041
      UniProtKB/TrEMBL
      Q545V6
      Related
      ENSMUSP00000004480.4, ENSMUST00000004480.5
      Conserved Domains (1) summary
      pfam03002
      Location:99 → 116
      Somatostatin; Somatostatin/Cortistatin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      23708327..23710041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60041.1 GenPept UniProtKB/Swiss-Prot:P60041

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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