Tgs1 trimethylguanosine synthase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tgs1provided by MGI
Official Full Name: trimethylguanosine synthase 1provided by MGI
Primary source: MGI:MGI:2151797
See related: Ensembl:ENSMUSG00000028233 AllianceGenome:MGI:2151797
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pimt; Ncoa6ip; D4Ertd800e
Summary: Predicted to enable RNA cap trimethylguanosine synthase activity. Predicted to be involved in 7-methylguanosine cap hypermethylation. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TGS1 (trimethylguanosine synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 11.1), CNS E14 (RPKM 7.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A1; 4 1.99 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (3574875..3616624)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (3574841..3616624)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice.
Title: TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice.
TGS1/PIMT regulates pro-inflammatory macrophage mediated paracrine insulin resistance: Crosstalk between macrophages and skeletal muscle cells.
Title: TGS1/PIMT regulates pro-inflammatory macrophage mediated paracrine insulin resistance: Crosstalk between macrophages and skeletal muscle cells.
PIMT Controls Insulin Synthesis and Secretion through PDX1.
Title: PIMT Controls Insulin Synthesis and Secretion through PDX1.
Trimethylguanosine synthase 1 is a novel regulator of pancreatic beta-cell mass and function.
Title: Trimethylguanosine synthase 1 is a novel regulator of pancreatic beta-cell mass and function.
PIMT is expressed in all cells of the E3.5day blastocyst in the mouse.
Title: Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB224415 (e-PCR)
- UniSTS:208263

Tgs1 (e-PCR), detects polymorphism
- UniSTS:479180

D4Ertd800e (e-PCR), detects polymorphism
- UniSTS:167416

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA cap trimethylguanosine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap trimethylguanosine synthase activity	IEA Inferred from Electronic Annotation more info
enables RNA cap trimethylguanosine synthase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 7-methylguanosine cap hypermethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in 7-methylguanosine cap hypermethylation	IEA Inferred from Electronic Annotation more info
involved_in 7-methylguanosine cap hypermethylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: trimethylguanosine synthase

Names: PIPMT; PRIP-interacting protein with methyltransferase motif; cap-specific guanine-N(2) methyltransferase; nuclear receptor coactivator 6-interacting protein; trimethylguanosine synthase homolog

NP_473430.3

EC 2.1.1.-

XP_006537621.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054089.4 → NP_473430.3 trimethylguanosine synthase

See identical proteins and their annotated locations for NP_473430.3

Status: VALIDATED

Source sequence(s)

AK044895, BC075728

Consensus CDS

CCDS17938.1

UniProtKB/Swiss-Prot

A2AJF7, Q6DI60, Q6PEA7, Q8R0W9, Q923W1

Related

ENSMUSP00000054112.6, ENSMUST00000052712.6

Conserved Domains (1) summary

pfam09445
Location:683 → 835

Methyltransf_15; RNA cap guanine-N2 methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

3574875..3616624

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537558.4 → XP_006537621.1 trimethylguanosine synthase isoform X1

Conserved Domains (1) summary

cl17173
Location:594 → 746

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...