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    Trmt10a tRNA methyltransferase 10A [ Mus musculus (house mouse) ]

    Gene ID: 108943, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Trmt10aprovided by MGI
    Official Full Name
    tRNA methyltransferase 10Aprovided by MGI
    Primary source
    MGI:MGI:1920421
    See related
    Ensembl:ENSMUSG00000004127 AllianceGenome:MGI:1920421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnmtd2; Rg9mtd2; 3110023L08Rik
    Summary
    Predicted to enable tRNA (guanosine(9)-N1)-methyltransferase activity and tRNA binding activity. Acts upstream of or within magnesium ion homeostasis. Predicted to be located in actin cytoskeleton and nucleolus. Predicted to be active in cytosol and nucleoplasm. Is expressed in Meckel's cartilage; cerebral cortex ventricular layer; skeleton; and ventral grey horn. Orthologous to human TRMT10A (tRNA methyltransferase 10A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 8.1), CNS E11.5 (RPKM 2.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trmt10a in Genome Data Viewer
    Location:
    3 G3; 3 64.09 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137849214..137865582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138143448..138159821)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110002E22 gene Neighboring gene STARR-seq mESC enhancer starr_09105 Neighboring gene predicted gene, 52617 Neighboring gene microsomal triglyceride transfer protein Neighboring gene STARR-positive B cell enhancer mm9_chr3:137778444-137778744 Neighboring gene STARR-seq mESC enhancer starr_09106 Neighboring gene STARR-positive B cell enhancer ABC_E3473 Neighboring gene RIKEN cDNA 4930579F01 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:137861123-137861424 Neighboring gene RIKEN cDNA 0610031O16 gene Neighboring gene alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Tresky R, et al. Nucleic Acids Res, 2024 Aug 27. PMID 38950903, Free PMC Article
    2. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. White JK, et al. Cell, 2013 Jul 18. PMID 23870131, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107421, MGC116571

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tRNA (guanosine(9)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanosine(9)-N1)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within magnesium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA N1-guanine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA methyltransferase 10 homolog A
    Names
    RNA (guanine-9-) methyltransferase domain containing 2
    tRNA (guanine(9)-N(1))-methyltransferase TRMT10A
    NP_001335125.2
    NP_001335126.2
    NP_001391294.1
    NP_001391297.1
    NP_001391298.1
    NP_001391299.1
    NP_001391300.1
    NP_001391301.1
    NP_001391302.1
    NP_001391303.1
    NP_001391304.1
    NP_001391305.1
    NP_001391307.1
    NP_001391308.1
    NP_001391309.1
    NP_001391310.1
    NP_001391311.1
    NP_001391312.1
    NP_001391313.1
    NP_001391314.1
    NP_001391315.1
    NP_780598.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348196.2 → NP_001335125.2  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      Consensus CDS
      CCDS17866.1
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8
      Related
      ENSMUSP00000125749.3, ENSMUST00000162864.8

    2. NM_001348197.2 → NP_001335126.2  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      Consensus CDS
      CCDS17866.1
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    3. NM_001404365.1 → NP_001391294.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    4. NM_001404368.1 → NP_001391297.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    5. NM_001404369.1 → NP_001391298.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    6. NM_001404370.1 → NP_001391299.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    7. NM_001404371.1 → NP_001391300.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    8. NM_001404372.1 → NP_001391301.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    9. NM_001404373.1 → NP_001391302.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    10. NM_001404374.1 → NP_001391303.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    11. NM_001404375.1 → NP_001391304.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    12. NM_001404376.1 → NP_001391305.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    13. NM_001404378.1 → NP_001391307.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    14. NM_001404379.1 → NP_001391308.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    15. NM_001404380.1 → NP_001391309.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    16. NM_001404381.1 → NP_001391310.1  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8

    17. NM_001404382.1 → NP_001391311.1  tRNA methyltransferase 10 homolog A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131122
      UniProtKB/TrEMBL
      B9EIT8

    18. NM_001404383.1 → NP_001391312.1  tRNA methyltransferase 10 homolog A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131122

    19. NM_001404384.1 → NP_001391313.1  tRNA methyltransferase 10 homolog A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131122

    20. NM_001404385.1 → NP_001391314.1  tRNA methyltransferase 10 homolog A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131122

    21. NM_001404386.1 → NP_001391315.1  tRNA methyltransferase 10 homolog A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC131122

    22. NM_175389.6 → NP_780598.3  tRNA methyltransferase 10 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131122
      Consensus CDS
      CCDS17866.1
      UniProtKB/TrEMBL
      A0A0R4J205, B9EIT8
      Related
      ENSMUSP00000042082.8, ENSMUST00000040321.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137849214..137865582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C1Z8.2 GenPept UniProtKB/Swiss-Prot:Q8C1Z8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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