Xpot exportin, tRNA (nuclear export receptor for tRNAs) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xpotprovided by MGI
Official Full Name: exportin, tRNA (nuclear export receptor for tRNAs)provided by MGI
Primary source: MGI:MGI:1920442
See related: Ensembl:ENSMUSG00000034667 AllianceGenome:MGI:1920442
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EXPORTIN-T; 1110004L07Rik; 3110065H13Rik
Summary: Predicted to enable tRNA binding activity. Predicted to be involved in tRNA re-export from nucleus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm and nuclear matrix. Is expressed in several structures, including endocrine gland; female reproductive system; mammary gland; oral epithelium; and trigeminal nerve. Orthologous to human XPOT (exportin for tRNA). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 13.2), liver E14 (RPKM 10.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 69.86 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (121423285..121462411, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (121587380..121626506, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141504 (e-PCR)
- UniSTS:223498

AI452076 (e-PCR)
- UniSTS:160036

RH126705 (e-PCR)
- UniSTS:208616

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in tRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in tRNA re-export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA re-export from nucleus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nuclear matrix	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exportin-T

Names: exportin(tRNA); tRNA exportin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081056.3 → NP_001074525.1 exportin-T isoform 1

Status: VALIDATED

Source sequence(s)

AC124413, AC124992

Consensus CDS

CCDS88093.1

UniProtKB/Swiss-Prot

Q52KI1, Q9CRT8

UniProtKB/TrEMBL

A0A1W2P7Q6

Related

ENSMUSP00000151722.2, ENSMUST00000218004.2

Conserved Domains (2) summary

smart00913
Location:21 → 88

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:100 → 247

Xpo1; Exportin 1-like protein
NM_001359618.2 → NP_001346547.1 exportin-T isoform 1

Status: VALIDATED

Source sequence(s)

AC124413, AC124992

Consensus CDS

CCDS88093.1

UniProtKB/Swiss-Prot

Q52KI1, Q9CRT8

UniProtKB/TrEMBL

A0A1W2P7Q6

Conserved Domains (2) summary

smart00913
Location:21 → 88

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:100 → 247

Xpo1; Exportin 1-like protein
NM_001401044.1 → NP_001387973.1 exportin-T isoform 2

Status: VALIDATED

Source sequence(s)

AC124413, AC124992

UniProtKB/Swiss-Prot

Q52KI1, Q9CRT8
NM_001401045.1 → NP_001387974.1 exportin-T isoform 3

Status: VALIDATED

Source sequence(s)

AC124413, AC124992

UniProtKB/Swiss-Prot

Q52KI1, Q9CRT8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

121423285..121462411 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245308.1 → XP_030101168.1 exportin-T isoform X3

UniProtKB/Swiss-Prot

Q52KI1, Q9CRT8

Conserved Domains (1) summary

pfam08389
Location:6 → 137

Xpo1; Exportin 1-like protein
XM_006514208.5 → XP_006514271.1 exportin-T isoform X3

UniProtKB/Swiss-Prot

Q52KI1, Q9CRT8

Conserved Domains (1) summary

pfam08389
Location:6 → 137

Xpo1; Exportin 1-like protein
XM_030245306.2 → XP_030101166.1 exportin-T isoform X1

UniProtKB/Swiss-Prot

Q52KI1, Q9CRT8

Conserved Domains (2) summary

smart00913
Location:21 → 88

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:98 → 245

Xpo1; Exportin 1-like protein
XM_006514206.4 → XP_006514269.1 exportin-T isoform X1

UniProtKB/Swiss-Prot

Q52KI1, Q9CRT8

Conserved Domains (2) summary

smart00913
Location:21 → 88

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:98 → 245

Xpo1; Exportin 1-like protein
XM_006514207.5 → XP_006514270.1 exportin-T isoform X2

UniProtKB/Swiss-Prot

Q52KI1, Q9CRT8

Conserved Domains (2) summary

smart00913
Location:21 → 88

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:100 → 247

Xpo1; Exportin 1-like protein