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    Col15a1 collagen, type XV, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 12819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Col15a1provided by MGI
    Official Full Name
    collagen, type XV, alpha 1provided by MGI
    Primary source
    MGI:MGI:88449
    See related
    Ensembl:ENSMUSG00000028339 AllianceGenome:MGI:88449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization. Located in basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; metatarsal bone; and nervous system. Orthologous to human COL15A1 (collagen type XV alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 90.5), genital fat pad adult (RPKM 48.4) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Col15a1 in Genome Data Viewer
    Location:
    4 B1; 4 26.01 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (47207744..47313165)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (47207655..47313167)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568655 Neighboring gene STARR-seq mESC enhancer starr_10140 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 12 Neighboring gene predicted gene, 52731 Neighboring gene predicted gene 12426 Neighboring gene STARR-positive B cell enhancer ABC_E4624 Neighboring gene predicted gene, 32317 Neighboring gene predicted gene, 52733 Neighboring gene STARR-seq mESC enhancer starr_10142 Neighboring gene predicted gene, 52734 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47323184-47323385 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47332572-47332788 Neighboring gene predicted gene, 52732 Neighboring gene STARR-positive B cell enhancer ABC_E10235 Neighboring gene predicted gene, 42282 Neighboring gene predicted gene, 32435 Neighboring gene transforming growth factor, beta receptor I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Eklund L, et al. Proc Natl Acad Sci U S A, 2001 Jan 30. PMID 11158616, Free PMC Article
    2. Protein expression pattern of collagen type XV in mouse cornea. Saika S, et al. Graefes Arch Clin Exp Ophthalmol, 2004 May. PMID 14752666
    3. Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model. Martínez-Nieto G, et al. Int J Mol Sci, 2021 Sep 15. PMID 34576139, Free PMC Article
    4. Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy. Rasi K, et al. Circ Res, 2010 Nov 12. PMID 20847313
    5. Cloning of mouse type XV collagen sequences and mapping of the corresponding gene to 4B1-3. Comparison of mouse and human alpha 1 (XV) collagen sequences indicates divergence in the number of small collagenous domains. Hägg PM, et al. Genomics, 1997 Oct 1. PMID 9339358

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model.
      Title: Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model.
    2. Mmu_circ_003795 regulates osteoblast differentiation and mineralization in MC3T3E1 and MDPC23 by targeting COL15A1.
      Title: Mmu_circ_003795 regulates osteoblast differentiation and mineralization in MC3T3‑E1 and MDPC23 by targeting COL15A1.
    3. The neuroprotection observed in ColXV KO mice may be attributed to the increased VEGF-A production following stroke in the ischemic territory.
      Title: Lack of collagen XV is protective after ischemic stroke in mice.
    4. loss of Col15a1resulted in marked attenuation rather than exacerbation of lesion pathogenesis
      Title: Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.
    5. Basement membrane zone collagens XV and XVIII mediate leukocyte influx in renal ischemia-reperfusion.
      Title: Basement membrane zone collagens XV and XVIII/proteoglycans mediate leukocyte influx in renal ischemia/reperfusion.
    6. Col XV is necessary for extracellular matrix organization in the heart, and for the structure and functions of microvessels. Col XV deficiency leads to a complex cardiac phenotype and predisposes the subject to pathological responses under cardiac stress.
      Title: Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy.
    7. Collagen XV thus contributes to peripheral nerve maturation and C-fiber formation
      Title: Lack of collagen XV impairs peripheral nerve maturation and, when combined with laminin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction.
    8. collagens XV and XVIII have distinct roles as revealed by double knockout mice
      Title: Double knockout mice reveal a lack of major functional compensation between collagens XV and XVIII.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent conferring tensile strength IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix structural constituent conferring tensile strength RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    collagen alpha-1(XV) chain
    Names
    procollagen type XV
    type XV collagen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009928.3 → NP_034058.2  collagen alpha-1(XV) chain precursor

      See identical proteins and their annotated locations for NP_034058.2

      Status: VALIDATED

      Source sequence(s)
      AF011450, AK134030, CJ099231
      Consensus CDS
      CCDS18159.1
      UniProtKB/Swiss-Prot
      A2AJY3, O35206, Q3UZ71, Q9EQD9
      UniProtKB/TrEMBL
      A2AJY2
      Related
      ENSMUSP00000099981.5, ENSMUST00000102917.11
      Conserved Domains (4) summary
      smart00210
      Location:42 → 228
      TSPN; Thrombospondin N-terminal -like domains
      pfam05109
      Location:265 → 541
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01391
      Location:641 → 690
      Collagen; Collagen triple helix repeat (20 copies)
      pfam06482
      Location:1114 → 1361
      Endostatin; Collagenase NC10 and Endostatin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      47207744..47313165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001784085.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35206.2 GenPept UniProtKB/Swiss-Prot:O35206

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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