TMT1 tonoplast monosaccharide transporter1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TMT1
Official Full Name: tonoplast monosaccharide transporter1
Primary source: TAIR:AT1G20840
Locus tag: AT1G20840
See related: Araport:AT1G20840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtTMT1; F9H16.18; F9H16_18; tonoplast monosaccharide transporter1
Summary: The protein encoded by this gene is found in the tonoplast (vacuole membrane) of Arabidopsis cells. The gene is expressed at highest levels in juvenile (sink) and adult (source) leaves, followed by flower tissues.
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Genomic context

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See TMT1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 6

Sequence:: Chromosome: 1; NC_003070.9 (7244939..7248494, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtSUC4 most likely catalyses proton-coupled sucrose export from the vacuole within the Arabidopsis cell. However, TMT1/2 probably represents a proton-coupled antiporter capable of high-capacity loading of glucose and sucrose into the vacuole.
Title: Proton-driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2.
VIK-dependent phosphorylation stimulates TMT1 transport activity.
Title: A member of the mitogen-activated protein 3-kinase family is involved in the regulation of plant vacuolar glucose uptake.
Increased TMT1 activity induced modified subcellular sugar compartmentation, altered cellular sugar sensing, affected assimilate allocation, increased the seed biomass, and accelerated early plant development.
Title: Increased activity of the vacuolar monosaccharide transporter TMT1 alters cellular sugar partitioning, sugar signaling, and seed yield in Arabidopsis.
These results indicate that TMT1 is involved in vacuolar monosaccharide transport and plays a major role during stress responses.[TMT1]
Title: Molecular identification and physiological characterization of a novel monosaccharide transporter from Arabidopsis involved in vacuolar sugar transport.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001332471.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleoside transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to cold	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to nematode	HEP more info	PubMed
involved_in response to salt	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sucrose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plant-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tonoplast monosaccharide transporter1

NP_001319055.1

tonoplast monosaccharide transporter1 (TMT1); FUNCTIONS IN: carbohydrate transmembrane transporter activity, sugar:hydrogen symporter activity, nucleoside transmembrane transporter activity; INVOLVED IN: in 6 processes; LOCATED IN: plant-type vacuole membrane, plasma membrane, vacuole, membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Sugar transporter, conserved site (InterPro:IPR005829), Major facilitator superfamily (InterPro:IPR020846), General substrate transporter (InterPro:IPR005828), Sugar/inositol transporter (InterPro:IPR003663), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: tonoplast monosaccharide transporter2 (TAIR:AT4G35300.4); Has 47782 Blast hits to 35006 proteins in 2411 species: Archae - 763; Bacteria - 22324; Metazoa - 7189; Fungi - 11789; Plants - 3723; Viruses - 0; Other Eukaryotes - 1994 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

7244939..7248494 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101937.6 → NP_173508.1 tonoplast monosaccharide transporter1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q96290, Q9LM67, Q9SYQ3

UniProtKB/TrEMBL

A0A178W059, A0A5S9VBJ9

Conserved Domains (1) summary

cl28910
Location:10 → 208

MFS; Major Facilitator Superfamily
NM_001332471.1 → NP_001319055.1 tonoplast monosaccharide transporter1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q96290, Q9LM67, Q9SYQ3

UniProtKB/TrEMBL

A0A178W059, A0A5S9VBJ9

Conserved Domains (1) summary

cl28910
Location:10 → 208

MFS; Major Facilitator Superfamily