Ptpn21 protein tyrosine phosphatase, non-receptor type 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn21provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 21provided by MGI
Primary source: MGI:MGI:1344406
See related: Ensembl:ENSMUSG00000021009 AllianceGenome:MGI:1344406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTPD1; PTPRL10
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human PTPN21 (protein tyrosine phosphatase non-receptor type 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 9.4), ovary adult (RPKM 9.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 49.88 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (98643000..98703664, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (98676741..98737613, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Ptpn21 maintains cellular mechanics, which is correlated with its important functions in Hematopoietic stem cell (HSC) niche retention and preservation of hematopoietic regeneration capacity.
Title: Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Study shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells.
Title: PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
PTPD1 is a component of a multivalent scaffold complex nucleated by FAK at specific intracellular sites
Title: Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 21

Names: protein-tyrosine phosphatase PTP-RL10

NP_001139671.1

EC 3.1.3.48

NP_036007.2

EC 3.1.3.48

XP_011242414.1

EC 3.1.3.48

XP_036013301.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146199.1 → NP_001139671.1 tyrosine-protein phosphatase non-receptor type 21

See identical proteins and their annotated locations for NP_001139671.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC124516, AC159193, BC098500

Consensus CDS

CCDS26098.1

UniProtKB/TrEMBL

G5E8J4, Q4KML9

Related

ENSMUSP00000126975.2, ENSMUST00000170188.8

Conserved Domains (6) summary

smart00194
Location:898 → 1168

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00295
Location:24 → 222

B41; Band 4.1 homologues

cd00047
Location:925 → 1168

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd13188
Location:217 → 307

FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)

pfam00373
Location:109 → 220

FERM_M; FERM central domain

pfam09379
Location:27 → 90

FERM_N; FERM N-terminal domain
NM_011877.2 → NP_036007.2 tyrosine-protein phosphatase non-receptor type 21

See identical proteins and their annotated locations for NP_036007.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC124516, AC159193, BC098500

Consensus CDS

CCDS26098.1

UniProtKB/TrEMBL

G5E8J4, Q4KML9

Related

ENSMUSP00000082197.3, ENSMUST00000085116.4

Conserved Domains (6) summary

smart00194
Location:898 → 1168

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00295
Location:24 → 222

B41; Band 4.1 homologues

cd00047
Location:925 → 1168

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd13188
Location:217 → 307

FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)

pfam00373
Location:109 → 220

FERM_M; FERM central domain

pfam09379
Location:27 → 90

FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

98643000..98703664 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244112.4 → XP_011242414.1 tyrosine-protein phosphatase non-receptor type 21 isoform X1

UniProtKB/TrEMBL

Q7TMG1

Conserved Domains (1) summary

cl28904
Location:471 → 757

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036157408.1 → XP_036013301.1 tyrosine-protein phosphatase non-receptor type 21 isoform X1

UniProtKB/TrEMBL

Q7TMG1

Conserved Domains (1) summary

cl28904
Location:471 → 757

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily