Ephb4 Eph receptor B4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ephb4provided by MGI
Official Full Name: Eph receptor B4provided by MGI
Primary source: MGI:MGI:104757
See related: Ensembl:ENSMUSG00000029710 AllianceGenome:MGI:104757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Htk; MDK2; Myk1; Tyro11; b2b2412Clo
Summary: Predicted to enable ephrin receptor activity. Involved in angiogenesis; ephrin receptor signaling pathway; and heart morphogenesis. Acts upstream of or within positive regulation of T cell costimulation; positive regulation of aorta morphogenesis; and venous blood vessel morphogenesis. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in central conducting lymphatic anomaly. Orthologous to human EPHB4 (EPH receptor B4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 50.3), limb E14.5 (RPKM 38.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.38 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137348371..137372784)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137350109..137374522)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortiondagger.
Title: EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortion†.
Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
Title: Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake.
Title: Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake.
Insulin induces insulin receptor degradation in the liver through EphB4.
Title: Insulin induces insulin receptor degradation in the liver through EphB4.
EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
Title: EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
Title: Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
Mutations in EPHB4 cause human venous valve aplasia.
Title: Mutations in EPHB4 cause human venous valve aplasia.
Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke.
Title: Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke.
Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
Title: Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.
Title: Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (8) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ephb4 (e-PCR), detects polymorphism
- UniSTS:495890

AI042935 (e-PCR)
- UniSTS:165433

Ephb4 (e-PCR), detects polymorphism
- UniSTS:142996

Ephb4 (e-PCR), detects polymorphism
- UniSTS:496828

Ephb4 (e-PCR), detects polymorphism
- UniSTS:527341

UniSTS:266994 (e-PCR)
- UniSTS:266994

Ephb4 (e-PCR), detects polymorphism
- UniSTS:266994

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell costimulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within venous blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ephrin type-B receptor 4

Names: developmental kinase 2; hepatoma transmembrane kinase; mDK-2; tyrosine kinase MYK-1

NP_001153043.1

EC 2.7.10.1

NP_034274.4

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159571.1 → NP_001153043.1 ephrin type-B receptor 4 isoform a precursor

See identical proteins and their annotated locations for NP_001153043.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK046884, AK049340, BB677774

Consensus CDS

CCDS51671.1

UniProtKB/TrEMBL

Q3V1K8, Q8C7S3, Q8C8K1

Related

ENSMUSP00000106684.3, ENSMUST00000111055.9

Conserved Domains (7) summary

cd05065
Location:619 → 887

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09554
Location:916 → 982

SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors

smart00454
Location:913 → 980

SAM; Sterile alpha motif

cd10474
Location:17 → 196

EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4

cd00063
Location:443 → 535

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07714
Location:624 → 883

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:571 → 619

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
NM_010144.6 → NP_034274.4 ephrin type-B receptor 4 isoform b precursor

See identical proteins and their annotated locations for NP_034274.4

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.

Source sequence(s)

AK049340, AK132392, BB677774, BC090839

Consensus CDS

CCDS19767.1

UniProtKB/Swiss-Prot

P54761, Q60627, Q99MR2

UniProtKB/TrEMBL

Q3V1K8, Q8C7S3

Related

ENSMUSP00000051622.9, ENSMUST00000061244.15

Conserved Domains (7) summary

cd05065
Location:610 → 878

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09554
Location:907 → 973

SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors

smart00454
Location:904 → 971

SAM; Sterile alpha motif

cd10474
Location:17 → 196

EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4

cd00063
Location:434 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07714
Location:615 → 874

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:562 → 610

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain