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    Zfp39 zinc finger protein 39 [ Mus musculus (house mouse) ]

    Gene ID: 22698, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp39provided by MGI
    Official Full Name
    zinc finger protein 39provided by MGI
    Primary source
    MGI:MGI:99183
    See related
    Ensembl:ENSMUSG00000037001 AllianceGenome:MGI:99183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp-39; CTfin33
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; and trunk somite. Orthologous to human ZNF717 (zinc finger protein 717). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 13.6), liver E14 (RPKM 3.6) and 17 other tissues See more
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    Genomic context

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    See Zfp39 in Genome Data Viewer
    Location:
    11 B1.3; 11 36.35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58778979..58795051, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58888153..58904225, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E588 Neighboring gene olfactory receptor family 9 subfamily E member 1 Neighboring gene predicted gene 12258 Neighboring gene RIKEN cDNA 2810021J22 gene Neighboring gene STARR-positive B cell enhancer ABC_E9824 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58697199-58697308 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58697335-58697545 Neighboring gene STARR-positive B cell enhancer ABC_E2990 Neighboring gene predicted gene 12257 Neighboring gene butyrophilin-like 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis. Noce T, et al. Dev Biol, 1992 Oct. PMID 1397691
    2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 39

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011758.2 → NP_035888.2  zinc finger protein 39

      See identical proteins and their annotated locations for NP_035888.2

      Status: VALIDATED

      Source sequence(s)
      AK045944, AK141135
      Consensus CDS
      CCDS24752.1
      UniProtKB/Swiss-Prot
      Q02525, Q2YDX7, Q5NC60, Q8BL91
      Related
      ENSMUSP00000099764.2, ENSMUST00000102703.2
      Conserved Domains (6) summary
      smart00349
      Location:59 → 118
      KRAB; krueppel associated box
      COG5048
      Location:407 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:355 → 374
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:59 → 98
      KRAB; KRAB box
      pfam13465
      Location:535 → 560
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58778979..58795051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02525.2 GenPept UniProtKB/Swiss-Prot:Q02525

    Gene LinkOut

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