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    Zfy2 zinc finger protein 2, Y-linked [ Mus musculus (house mouse) ]

    Gene ID: 22768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfy2provided by MGI
    Official Full Name
    zinc finger protein 2, Y-linkedprovided by MGI
    Primary source
    MGI:MGI:99213
    See related
    Ensembl:ENSMUSG00000000103 AllianceGenome:MGI:99213
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfy-2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within dosage compensation by inactivation of X chromosome; meiotic recombination checkpoint signaling; and spermatid development. Predicted to be active in nucleus. Is expressed in heart; liver; lung; metanephros; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 1.1) See more
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    Genomic context

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    See Zfy2 in Genome Data Viewer
    Location:
    Y; Ypter
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (2106175..2170409, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (2106175..2170409, complement)

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-activating enzyme E1, Chr Y 1 pseudogene Neighboring gene ras homolog A translocated to the Y, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_48305 Neighboring gene ubiquitin-activating enzyme, Chr Y, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_48306 Neighboring gene ubiquitin-activating enzyme E1, Chr Y 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New assays for Y chromosome and p53 pseudogene clines among East Holstein house mice. Prager EM, et al. Mamm Genome, 1997 Apr. PMID 9096111
    2. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Su H, et al. Mol Reprod Dev, 1992 Nov. PMID 1449792
    3. Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction. Nakasuji T, et al. PLoS Genet, 2017 Jan. PMID 28114340, Free PMC Article
    4. The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers. Mardon G, et al. Cell, 1989 Mar 10. PMID 2493989
    5. A genomic clone of Zfy-1 from a YDOM mouse strain detects post-meiotic gene expression of Zfy in testes. Kalikin LM, et al. Biochem Biophys Res Commun, 1989 Dec 29. PMID 2514683

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
      Title: Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
    2. we show that in mice, Zfy genes(Zfy1 and Zfy2 ) are also necessary for efficient meiotic sex chrand the sex chromosomes are not correctly silenced in Zfy-deficient spermatocytes.
      Title: Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes.
    3. Zfy2-KO mice did not show any significant phenotypic alterations. Zfy1/2-DKO mice were infertile and displayed abnormal sperm morphology and fertilization failure.
      Title: Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.
    4. Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development
      Title: Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development.
    5. Zfy2 is essential for sperm formation and is essential for sperm function in assisted fertilization procedure.
      Title: Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization.
    6. Zfy2 proved to be essential for the efficient operation of a 'checkpoint' during the first meiotic division that identifies and kills cells that would otherwise produce sperm with an unbalanced chromosome set.
      Title: Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division.
    7. The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility.
      Title: The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility.
    8. Studies identified a Zfy2 transcript that predominates in spermatids, and a Zfy1 transcript, lacking an exon encoding approximately half of the acidic domain.
      Title: Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
    9. Zfy2 (but not the closely related Zfy1) is sufficient to reinstate the apoptotic response to the X univalent meiotic cell.
      Title: The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dosage compensation by inactivation of X chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic recombination checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatid development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger Y-chromosomal protein 2
    Names
    Y-linked zinc finger protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009571.2 → NP_033597.2  zinc finger Y-chromosomal protein 2

      See identical proteins and their annotated locations for NP_033597.2

      Status: PROVISIONAL

      Source sequence(s)
      AK133222
      Consensus CDS
      CCDS41217.1
      UniProtKB/Swiss-Prot
      P20662, Q3V0D8
      Related
      ENSMUSP00000111557.2, ENSMUST00000115891.2
      Conserved Domains (6) summary
      COG5048
      Location:442 → 681
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:522 → 542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:520 → 542
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:68 → 388
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:534 → 556
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      2106175..2170409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318690.2 → XP_017174179.1  zinc finger Y-chromosomal protein 2 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:427 → 666
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:390 → 410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam04704
      Location:42 → 373
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20662.2 GenPept UniProtKB/Swiss-Prot:P20662

    Gene LinkOut

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