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    Cand2 cullin associated and neddylation dissociated 2 (putative) [ Mus musculus (house mouse) ]

    Gene ID: 67088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cand2provided by MGI
    Official Full Name
    cullin associated and neddylation dissociated 2 (putative)provided by MGI
    Primary source
    MGI:MGI:1914338
    See related
    Ensembl:ENSMUSG00000030319 AllianceGenome:MGI:1914338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tp120b; mKIAA0667; 2210404G23Rik
    Summary
    Enables TBP-class protein binding activity. Predicted to be involved in SCF complex assembly and protein ubiquitination. Located in nucleus. Is expressed in several structures, including limb bud; musculature; and nervous system. Orthologous to human CAND2 (cullin associated and neddylation dissociated 2 (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 24.2), heart adult (RPKM 22.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cand2 in Genome Data Viewer
    Location:
    6 E3; 6 53.71 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115751518..115782516)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115774557..115805555)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 40 Neighboring gene STARR-seq mESC enhancer starr_17094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115724212-115724399 Neighboring gene predicted gene, 44180 Neighboring gene microRNA 7660 Neighboring gene STARR-positive B cell enhancer ABC_E4857 Neighboring gene small nucleolar RNA, H/ACA box 7A Neighboring gene ribosomal protein L32 Neighboring gene EF-hand calcium binding domain 12 Neighboring gene STARR-positive B cell enhancer ABC_E2201

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity. Dong SS, et al. Int J Obes (Lond), 2019 Mar. PMID 29717274, Free PMC Article
    2. TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3. Aoki T, et al. Biochem Biophys Res Commun, 2002 Sep 6. PMID 12207886
    3. TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. Shiraishi S, et al. J Biol Chem, 2007 Mar 23. PMID 17242400
    4. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues. Aoki T, et al. Biochem Biophys Res Commun, 1999 Aug 11. PMID 10441524
    5. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Ling KH, et al. Genome Biol, 2009. PMID 19799774, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAND2 inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation
      Title: TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables TBP-class protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cullin-associated NEDD8-dissociated protein 2
    Names
    TBP-interacting protein 120B
    TBP-interacting protein b
    TBP-interacting protein of 120 kDa B
    cullin-associated and neddylation-dissociated protein 2
    p120 CAND2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025958.2 → NP_080234.2  cullin-associated NEDD8-dissociated protein 2

      See identical proteins and their annotated locations for NP_080234.2

      Status: VALIDATED

      Source sequence(s)
      BC056365, BC058338, BP761509, BY553771, CJ299742
      Consensus CDS
      CCDS20442.1
      UniProtKB/Swiss-Prot
      Q6PHT7, Q6ZQ73
      UniProtKB/TrEMBL
      Q3UM57
      Related
      ENSMUSP00000075377.6, ENSMUST00000075995.7
      Conserved Domains (3) summary
      pfam08623
      Location:1057 → 1206
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13513
      Location:150 → 202
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:864 → 886
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      115751518..115782516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255552.2 → XP_030111412.1  cullin-associated NEDD8-dissociated protein 2 isoform X1

      Conserved Domains (4) summary
      COG1413
      Location:392 → 558
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:391 → 413
      HEAT; HEAT repeat [structural motif]
      pfam08623
      Location:584 → 733
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13513
      Location:367 → 414
      HEAT_EZ; HEAT-like repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQ73.2 GenPept UniProtKB/Swiss-Prot:Q6ZQ73

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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