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    Emc6 ER membrane protein complex subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 66048, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Emc6provided by MGI
    Official Full Name
    ER membrane protein complex subunit 6provided by MGI
    Primary source
    MGI:MGI:1913298
    See related
    Ensembl:ENSMUSG00000047260 AllianceGenome:MGI:1913298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem93; 0610009E20Rik; 0610025L18Rik
    Summary
    Predicted to contribute to membrane insertase activity. Predicted to be involved in autophagosome assembly; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane and omegasome membrane. Predicted to be part of EMC complex. Is expressed in several structures, including bladder; central nervous system; liver; pancreas; and skin. Orthologous to human EMC6 (ER membrane protein complex subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 42.4), mammary gland adult (RPKM 30.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Emc6 in Genome Data Viewer
    Location:
    11 B4; 11 45.25 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (73066329..73067868, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73175503..73177042, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene integrin alpha E, epithelial-associated Neighboring gene histone H3 associated protein kinase Neighboring gene STARR-seq mESC enhancer starr_29929 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 5 Neighboring gene STARR-positive B cell enhancer ABC_E1141 Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 3 Neighboring gene cystinosis, nephropathic

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway. Li R, et al. Biochem Biophys Res Commun, 2019 Jun 4. PMID 30982575
    2. The ER membrane protein complex is a transmembrane domain insertase. Guna A, et al. Science, 2018 Jan 26. PMID 29242231, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to membrane insertase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of EMC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in omegasome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in omegasome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 6
    Names
    transmembrane protein 93

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168470.1 → NP_001161942.1  ER membrane protein complex subunit 6

      See identical proteins and their annotated locations for NP_001161942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL670399, DV661517
      Consensus CDS
      CCDS24999.1
      UniProtKB/Swiss-Prot
      Q9CQ41, Q9CQW0
      Related
      ENSMUSP00000104120.2, ENSMUST00000108480.2
      Conserved Domains (1) summary
      pfam07019
      Location:25 → 101
      Rab5ip; Rab5-interacting protein (Rab5ip)

    2. NM_025318.3 → NP_079594.1  ER membrane protein complex subunit 6

      See identical proteins and their annotated locations for NP_079594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK003198, AK004149, AL670399
      Consensus CDS
      CCDS24999.1
      UniProtKB/Swiss-Prot
      Q9CQ41, Q9CQW0
      Related
      ENSMUSP00000060892.4, ENSMUST00000054952.4
      Conserved Domains (1) summary
      pfam07019
      Location:25 → 101
      Rab5ip; Rab5-interacting protein (Rab5ip)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      73066329..73067868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQW0.1 GenPept UniProtKB/Swiss-Prot:Q9CQW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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