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    Efnb1 ephrin B1 [ Mus musculus (house mouse) ]

    Gene ID: 13641, updated on 9-Dec-2024

    Summary

    Official Symbol
    Efnb1provided by MGI
    Official Full Name
    ephrin B1provided by MGI
    Primary source
    MGI:MGI:102708
    See related
    Ensembl:ENSMUSG00000031217 AllianceGenome:MGI:102708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Epl2; EFL-3; Elk-L; Eplg2; Lerk2; Stra1; Cek5-L; LERK-2
    Summary
    This gene encodes a membrane protein that acts as a ligand for Eph family receptors. Signalling occurs bidirectionally in both the cell containing the receptor and the cell expressing this protein. Activity of this protein is important in neuronal axon growth and other developmental processes. [provided by RefSeq, May 2015]
    Expression
    Ubiquitous expression in lung adult (RPKM 47.3), colon adult (RPKM 44.5) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Efnb1 in Genome Data Viewer
    Location:
    X C3; X 43.22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (98179667..98192628)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (99136061..99149022)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 57677 Neighboring gene STARR-seq mESC enhancer starr_47612 Neighboring gene STARR-positive B cell enhancer ABC_E7702 Neighboring gene STARR-seq mESC enhancer starr_47613 Neighboring gene predicted gene, 30649 Neighboring gene predicted gene, 39528 Neighboring gene predicted gene, 30704

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (14)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ephrin-B1
    Names
    CEK5 receptor ligand
    Cek ligand
    ELK ligand
    EPH-related receptor tyrosine kinase ligand 2
    stimulated by retinoic acid gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010110.5NP_034240.1  ephrin-B1 precursor

      See identical proteins and their annotated locations for NP_034240.1

      Status: REVIEWED

      Source sequence(s)
      AK034996, AL671478, BI988800, BQ177892
      Consensus CDS
      CCDS30298.1
      UniProtKB/Swiss-Prot
      P52795
      UniProtKB/TrEMBL
      Q544L9
      Related
      ENSMUSP00000050716.7, ENSMUST00000052839.7
      Conserved Domains (1) summary
      cd10426
      Location:31165
      Ephrin-B_Ectodomain; Ectodomain of Ephrin B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      98179667..98192628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)