Arhgef18 Rho/Rac guanine nucleotide exchange factor 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgef18provided by MGI
Official Full Name: Rho/Rac guanine nucleotide exchange factor 18provided by MGI
Primary source: MGI:MGI:2142567
See related: Ensembl:ENSMUSG00000004568 AllianceGenome:MGI:2142567
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A430078G23Rik; D030053O22Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly; protein localization to cell-cell junction; and regulation of Rho protein signal transduction. Predicted to act upstream of or within actin cytoskeleton organization; regulation of cell shape; and small GTPase-mediated signal transduction. Predicted to be located in apical part of cell and cytosol. Predicted to be active in plasma membrane. Is expressed in brain; genitourinary system; integument; and liver. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 41.5), thymus adult (RPKM 26.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 1.92 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (3403339..3506601)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (3353338..3456601)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224750

AI467246 (e-PCR)
- UniSTS:159728

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell-cell junction	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 18

Names: rho/rac guanine nucleotide exchange factor (GEF) 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370668.1 → NP_001357597.1 rho guanine nucleotide exchange factor 18 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC169677

UniProtKB/Swiss-Prot

E9QK59, Q6A055, Q6P9R4, Q8BYA4, Q8K227

UniProtKB/TrEMBL

A0A5F8MPH6

Related

ENSMUSP00000158969.2, ENSMUST00000239102.2

Conserved Domains (4) summary

cd00160
Location:486 → 680

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:721 → 839

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:1044 → 1165

DUF5401; Family of unknown function (DUF5401)

cl28929
Location:1124 → 1276

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
NM_133962.4 → NP_598723.3 rho guanine nucleotide exchange factor 18 isoform 2

See identical proteins and their annotated locations for NP_598723.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) results from the use of an alternate downstream promoter and initiates translation from an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK041423, AK083608, BC060639, BQ830835, CA749983

Consensus CDS

CCDS22060.1

UniProtKB/TrEMBL

A0A5F8MPF6

Related

ENSMUSP00000004684.7, ENSMUST00000004684.13

Conserved Domains (4) summary

cd00160
Location:102 → 296

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:337 → 455

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:667 → 783

DUF5401; Family of unknown function (DUF5401)

cl28929
Location:740 → 892

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

3403339..3506601

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243210.2 → XP_030099070.1 rho guanine nucleotide exchange factor 18 isoform X2

UniProtKB/TrEMBL

A0A5F8MPH6

Conserved Domains (4) summary

PRK13729
Location:1132 → 1284

PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

cd00160
Location:486 → 680

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:721 → 839

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:1059 → 1176

DUF5401; Family of unknown function (DUF5401)
XM_030243212.2 → XP_030099072.1 rho guanine nucleotide exchange factor 18 isoform X3

UniProtKB/TrEMBL

A0A5F8MPH6

Conserved Domains (4) summary

PRK13729
Location:1071 → 1223

PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

cd00160
Location:425 → 619

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:660 → 778

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:998 → 1115

DUF5401; Family of unknown function (DUF5401)
XM_030243209.2 → XP_030099069.1 rho guanine nucleotide exchange factor 18 isoform X1

UniProtKB/TrEMBL

A0A5F8MPH6

Conserved Domains (4) summary

PRK13729
Location:1153 → 1305

PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

cd00160
Location:515 → 709

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:750 → 868

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:1080 → 1197

DUF5401; Family of unknown function (DUF5401)
XM_030243211.2 → XP_030099071.1 rho guanine nucleotide exchange factor 18 isoform X3

UniProtKB/TrEMBL

A0A5F8MPH6

Conserved Domains (4) summary

PRK13729
Location:1071 → 1223

PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

cd00160
Location:425 → 619

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:660 → 778

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:998 → 1115

DUF5401; Family of unknown function (DUF5401)
XM_006508682.4 → XP_006508745.1 rho guanine nucleotide exchange factor 18 isoform X4

See identical proteins and their annotated locations for XP_006508745.1

UniProtKB/TrEMBL

A0A5F8MPF6

Conserved Domains (4) summary

PRK13729
Location:748 → 900

PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

cd00160
Location:102 → 296

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:337 → 455

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:675 → 775

DUF5401; Family of unknown function (DUF5401)
XM_036153699.1 → XP_036009592.1 rho guanine nucleotide exchange factor 18 isoform X5

UniProtKB/TrEMBL

A0A5F8MPF6

Conserved Domains (4) summary

cd00160
Location:102 → 296

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:337 → 455

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:667 → 783

DUF5401; Family of unknown function (DUF5401)

cl28929
Location:740 → 892

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
XM_017312501.3 → XP_017167990.1 rho guanine nucleotide exchange factor 18 isoform X4

UniProtKB/TrEMBL

A0A5F8MPF6

Conserved Domains (4) summary

PRK13729
Location:748 → 900

PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

cd00160
Location:102 → 296

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:337 → 455

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:675 → 775

DUF5401; Family of unknown function (DUF5401)
XM_036153700.1 → XP_036009593.1 rho guanine nucleotide exchange factor 18 isoform X5

UniProtKB/TrEMBL

A0A5F8MPF6

Conserved Domains (4) summary

cd00160
Location:102 → 296

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:337 → 455

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:667 → 783

DUF5401; Family of unknown function (DUF5401)

cl28929
Location:740 → 892

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
XM_006508681.4 → XP_006508744.1 rho guanine nucleotide exchange factor 18 isoform X4

See identical proteins and their annotated locations for XP_006508744.1

UniProtKB/TrEMBL

A0A5F8MPF6

Conserved Domains (4) summary

PRK13729
Location:748 → 900

PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

cd00160
Location:102 → 296

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd15794
Location:337 → 455

PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

pfam17380
Location:675 → 775

DUF5401; Family of unknown function (DUF5401)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001033378.3: Suppressed sequence

Description

NM_001033378.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.