Ing2 inhibitor of growth family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ing2provided by MGI
Official Full Name: inhibitor of growth family, member 2provided by MGI
Primary source: MGI:MGI:1916510
See related: Ensembl:ENSMUSG00000063049 AllianceGenome:MGI:1916510
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ing1l; Ing2b; P33ING2; 2810011M06Rik
Summary: Predicted to enable DNA binding activity; methylated histone binding activity; and phosphatidylinositol binding activity. Involved in several processes, including male meiosis I; seminiferous tubule development; and spermatogenesis. Acts upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of CCAAT-binding activity factor complex and Sin3-type complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and immune system. Orthologous to human ING2 (inhibitor of growth family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 8.8), cortex adult (RPKM 5.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 26.87 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (48120213..48128627, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (47667178..47675159, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Title: Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
ING2 may play a crucial role in the process of preimplantation embryo development through chromatin regulation.
Title: ING2 (inhibitor of growth protein-2) plays a crucial role in preimplantation development.
ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis.
Title: Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis.
These findings define a novel function for ING2 in muscle differentiation.
Title: Identification of a novel function for the chromatin remodeling protein ING2 in muscle differentiation.
Study establishes ING2 as a novel regulator of spermatogenesis functioning, and provides an animal model to study idiopathic and iatrogenic infertility in men.
Title: Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas.
2.0 A resolution structure of the mouse ING2 PHD finger in complex with a histone H3 peptide trimethylated at lysine 4
Title: Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235889

BQ195509 (e-PCR)
- UniSTS:260521

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase regulator activity	TAS Traceable Author Statement more info	PubMed
enables histone reader activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression, epigenetic	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in seminiferous tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	IEA Inferred from Electronic Annotation more info
part_of CCAAT-binding factor complex	ISO Inferred from Sequence Orthology more info
part_of Sin3-type complex	ISO Inferred from Sequence Orthology more info
part_of Sin3-type complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Sin3-type complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inhibitor of growth protein 2

Names: inhibitor of growth 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023503.3 → NP_075992.2 inhibitor of growth protein 2

See identical proteins and their annotated locations for NP_075992.2

Status: VALIDATED

Source sequence(s)

AC107236

Consensus CDS

CCDS22298.1

UniProtKB/Swiss-Prot

Q4VAD7, Q80VI5, Q8BGU8, Q9ESK4

Related

ENSMUSP00000079226.3, ENSMUST00000080353.3

Conserved Domains (3) summary

COG5034
Location:31 → 260

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15683
Location:214 → 262

PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)

pfam12998
Location:28 → 122

ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

48120213..48128627 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154269.1 → XP_036010162.1 inhibitor of growth protein 2 isoform X1

UniProtKB/TrEMBL

B6ZI39

Conserved Domains (1) summary

cd15683
Location:107 → 155

PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
XM_036154268.1 → XP_036010161.1 inhibitor of growth protein 2 isoform X1

UniProtKB/TrEMBL

B6ZI39

Conserved Domains (1) summary

cd15683
Location:107 → 155

PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)