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    Tm4sf20 transmembrane 4 L six family member 20 [ Mus musculus (house mouse) ]

    Gene ID: 66261, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tm4sf20provided by MGI
    Official Full Name
    transmembrane 4 L six family member 20provided by MGI
    Primary source
    MGI:MGI:1913511
    See related
    Ensembl:ENSMUSG00000026149 AllianceGenome:MGI:1913511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810018L02Rik
    Summary
    Predicted to be involved in negative regulation of proteolysis. Predicted to be located in endoplasmic reticulum membrane; focal adhesion; and plasma membrane. Predicted to be active in membrane. Is expressed in alimentary system; central nervous system; lung; retina; and urethra. Human ortholog(s) of this gene implicated in specific language impairment. Orthologous to human TM4SF20 (transmembrane 4 L six family member 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 49.6), small intestine adult (RPKM 22.0) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tm4sf20 in Genome Data Viewer
    Location:
    1 C5; 1 42.48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (82734368..82746182, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (82756647..82768461, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 3 Neighboring gene RIKEN cDNA C430014B12 gene Neighboring gene STARR-seq mESC enhancer starr_01479 Neighboring gene mitochondrial fission factor Neighboring gene predicted gene, 19257 Neighboring gene predicted gene, 34286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Anderson KR, et al. Development, 2011 Aug. PMID 21750032, Free PMC Article
    2. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
    3. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143474

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 4 L6 family member 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368252.1 → NP_001355181.1  transmembrane 4 L6 family member 20 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
      Source sequence(s)
      AK007532, AK017195, AK017209, AV378190, BE686508

    2. NM_025453.4 → NP_079729.1  transmembrane 4 L6 family member 20 isoform 1

      See identical proteins and their annotated locations for NP_079729.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK007532, AK017195, AK017209, AV378190
      Consensus CDS
      CCDS15099.1
      UniProtKB/Swiss-Prot
      Q9CQY8, Q9D3Q0, Q9D3R0
      Related
      ENSMUSP00000027331.3, ENSMUST00000027331.3
      Conserved Domains (1) summary
      pfam05805
      Location:2 → 220
      L6_membrane; L6 membrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      82734368..82746182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQY8.1 GenPept UniProtKB/Swiss-Prot:Q9CQY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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