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    Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68652, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tab2provided by MGI
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by MGI
    Primary source
    MGI:MGI:1915902
    See related
    Ensembl:ENSMUSG00000015755 AllianceGenome:MGI:1915902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map3k7ip2; mKIAA0733; 1110030N06Rik; A530078N03Rik
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including non-canonical NF-kappaB signal transduction; positive regulation of canonical NF-kappaB signal transduction; and response to bacterium. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.4), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tab2 in Genome Data Viewer
    Location:
    10 A1; 10 2.56 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7781412..7832039, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7905648..7956255, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7559346-7559529 Neighboring gene STARR-seq mESC enhancer starr_25692 Neighboring gene zinc finger CCCH type containing 12D Neighboring gene microRNA 5104 Neighboring gene predicted gene, 24726 Neighboring gene STARR-seq mESC enhancer starr_25693 Neighboring gene STARR-seq mESC enhancer starr_25694 Neighboring gene predicted gene, 30820 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7785616-7785813 Neighboring gene STARR-seq mESC enhancer starr_25695 Neighboring gene STARR-seq mESC enhancer starr_25696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7904647-7904800 Neighboring gene predicted gene, 30906 Neighboring gene uronyl-2-sulfotransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables K63-linked polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
    Names
    TGF-beta-activated kinase 1-binding protein 2
    Tak1 binding protein 2
    mitogen-activated protein kinase kinase kinase 7-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359534.1NP_001346463.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      AC092856, AW492243, AY093701, CN532534
      Consensus CDS
      CCDS23691.1
      UniProtKB/Swiss-Prot
      Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4
      Conserved Domains (4) summary
      smart00547
      Location:667690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    2. NM_138667.3NP_619608.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

      See identical proteins and their annotated locations for NP_619608.1

      Status: VALIDATED

      Source sequence(s)
      AC092856, AK003993, AY093701, BF468714, BG078791, BY429748, CK391470
      Consensus CDS
      CCDS23691.1
      UniProtKB/Swiss-Prot
      Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4
      Related
      ENSMUSP00000121266.2, ENSMUST00000146444.8
      Conserved Domains (4) summary
      smart00547
      Location:667690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      7781412..7832039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243204.4XP_011241506.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011241506.1

      Conserved Domains (4) summary
      smart00547
      Location:693716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:563640
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:694713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    2. XM_011243203.4XP_011241505.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011241505.1

      Conserved Domains (4) summary
      smart00547
      Location:693716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:563640
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:694713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    3. XM_030245247.2XP_030101107.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      Conserved Domains (4) summary
      smart00547
      Location:693716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:563640
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:694713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    4. XM_036155973.1XP_036011866.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      Conserved Domains (4) summary
      smart00547
      Location:693716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:563640
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:694713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    5. XM_036155974.1XP_036011867.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4
      Conserved Domains (4) summary
      smart00547
      Location:667690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    6. XM_036155977.1XP_036011870.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      D3Z216
      Conserved Domains (1) summary
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    7. XM_036155976.1XP_036011869.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      D3Z216
      Conserved Domains (1) summary
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    8. XM_036155975.1XP_036011868.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      D3Z216
      Conserved Domains (1) summary
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins