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    Sppl3 signal peptide peptidase 3 [ Mus musculus (house mouse) ]

    Gene ID: 74585, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sppl3provided by MGI
    Official Full Name
    signal peptide peptidase 3provided by MGI
    Primary source
    MGI:MGI:1891433
    See related
    Ensembl:ENSMUSG00000029550 AllianceGenome:MGI:1891433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psl4; Usmg3; 4833416I09Rik
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in central nervous system; gonad; retina; and vibrissa. Orthologous to human SPPL3 (signal peptide peptidase like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 71.9), limb E14.5 (RPKM 43.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sppl3 in Genome Data Viewer
    Location:
    5 F; 5 55.99 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115149204..115236849)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115011524..115098790)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2210016L21 gene Neighboring gene STARR-positive B cell enhancer ABC_E1057 Neighboring gene HNF1 homeobox A Neighboring gene STARR-seq mESC enhancer starr_14093 Neighboring gene HNF1 homeobox A, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_14096 Neighboring gene STARR-seq mESC enhancer starr_14098 Neighboring gene STARR-seq mESC enhancer starr_14099 Neighboring gene predicted gene, 54336 Neighboring gene ribosomal protein L37, retrotransposed Neighboring gene acyl-Coenzyme A dehydrogenase, short chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. Kuhn PH, et al. Mol Cell Proteomics, 2015 Jun. PMID 25827571, Free PMC Article
    2. Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. Voss M, et al. EMBO J, 2014 Dec 17. PMID 25354954, Free PMC Article
    3. NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3. Hamblet CE, et al. J Immunol, 2016 Mar 15. PMID 26851218, Free PMC Article
    4. A protease-independent function for SPPL3 in NFAT activation. Makowski SL, et al. Mol Cell Biol, 2015 Jan. PMID 25384971, Free PMC Article
    5. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results identify SPPL3 as a cell-autonomous molecular determinant of NK cell maturation
      Title: NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90867

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane protein proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of calcineurin-NFAT signaling cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi-associated vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rough endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    signal peptide peptidase-like 3
    Names
    IMP-2
    SPP-like 3 protein
    intramembrane protease 2
    presenilin-like protein 4
    upregulated during skeletal muscle growth 3
    NP_083288.2
    XP_017176612.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029012.2 → NP_083288.2  signal peptide peptidase-like 3

      See identical proteins and their annotated locations for NP_083288.2

      Status: VALIDATED

      Source sequence(s)
      AK014709, BU613738, CAAA01026347, CD806412
      Consensus CDS
      CCDS19578.1
      UniProtKB/Swiss-Prot
      E9QP88, Q8R597, Q9CUS9
      UniProtKB/TrEMBL
      Q5RJH9
      Related
      ENSMUSP00000031530.6, ENSMUST00000031530.9
      Conserved Domains (1) summary
      pfam04258
      Location:61 → 374
      Peptidase_A22B; Signal peptide peptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115149204..115236849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321123.3 → XP_017176612.1  signal peptide peptidase-like 3 isoform X1

      Conserved Domains (1) summary
      pfam04258
      Location:1 → 288
      Peptidase_A22B; Signal peptide peptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CUS9.3 GenPept UniProtKB/Swiss-Prot:Q9CUS9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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