Rtkn rhotekin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rtknprovided by MGI
Official Full Name: rhotekinprovided by MGI
Primary source: MGI:MGI:107371
See related: Ensembl:ENSMUSG00000034930 AllianceGenome:MGI:107371
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to be located in cytosol. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 11.3), duodenum adult (RPKM 8.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83112485..83129560)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83135505..83152579)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings suggest that cGK-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation.
Title: cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6UmiJ11 (e-PCR), detects polymorphism
- UniSTS:260406

U54638 (e-PCR)
- UniSTS:163392

D6UmiJ9 (e-PCR), detects polymorphism
- UniSTS:260423

Rtkn (e-PCR), detects polymorphism
- UniSTS:144363

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: rhotekin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136227.2 → NP_001129699.1 rhotekin isoform a

See identical proteins and their annotated locations for NP_001129699.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform a.

Source sequence(s)

AC104324

Consensus CDS

CCDS51817.1

UniProtKB/Swiss-Prot

E9QM24, Q61192, Q8C6B2, Q8VIG7

Related

ENSMUSP00000065571.5, ENSMUST00000065512.11

Conserved Domains (4) summary

smart00742
Location:37 → 91

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam00169
Location:333 → 411

PH; PH domain

pfam08174
Location:117 → 270

Anillin; Cell division protein anillin

cl17171
Location:309 → 419

PH-like; Pleckstrin homology-like domain
NM_001355524.2 → NP_001342453.2 rhotekin isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is longer and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AC104324
NM_001355525.2 → NP_001342454.2 rhotekin isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, 5' coding region, 3' coding region, and 3' UTR, compared to variant 1. The resulting isoform (d) is shorter and has distinct N- and C-termini, compared to isoform a.

Source sequence(s)

AC104324
NM_001410312.1 → NP_001397241.1 rhotekin isoform e

Status: VALIDATED

Source sequence(s)

AC104324
NM_001410313.1 → NP_001397242.1 rhotekin isoform e

Status: VALIDATED

Source sequence(s)

AC104324
NM_001410314.1 → NP_001397243.1 rhotekin isoform f

Status: VALIDATED

Source sequence(s)

AC104324
NM_001410315.1 → NP_001397244.1 rhotekin isoform g

Status: VALIDATED

Source sequence(s)

AC104324
NM_001410316.1 → NP_001397245.1 rhotekin isoform h

Status: VALIDATED

Source sequence(s)

AC104324
NM_009106.3 → NP_033132.2 rhotekin isoform b

See identical proteins and their annotated locations for NP_033132.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AC104324

Consensus CDS

CCDS20274.1

UniProtKB/Swiss-Prot

Q8C6B2

Related

ENSMUSP00000112501.2, ENSMUST00000121093.8

Conserved Domains (4) summary

smart00742
Location:23 → 78

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam00169
Location:320 → 398

PH; PH domain

pfam08174
Location:104 → 257

Anillin; Cell division protein anillin

cl17171
Location:296 → 406

PH-like; Pleckstrin homology-like domain
NM_133641.3 → NP_598396.2 rhotekin isoform b

See identical proteins and their annotated locations for NP_598396.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AC104324

Consensus CDS

CCDS20274.1

UniProtKB/Swiss-Prot

Q8C6B2

Related

ENSMUSP00000085249.5, ENSMUST00000087938.11

Conserved Domains (4) summary

smart00742
Location:23 → 78

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam00169
Location:320 → 398

PH; PH domain

pfam08174
Location:104 → 257

Anillin; Cell division protein anillin

cl17171
Location:296 → 406

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

83112485..83129560

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505810.5 → XP_006505873.1 rhotekin isoform X4

See identical proteins and their annotated locations for XP_006505873.1

Conserved Domains (3) summary

pfam08174
Location:67 → 220

Anillin; Cell division protein anillin

cl00087
Location:1 → 41

HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

cl17171
Location:259 → 314

PH-like; Pleckstrin homology-like domain
XM_006505807.3 → XP_006505870.1 rhotekin isoform X2

Conserved Domains (3) summary

smart00742
Location:37 → 91

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam08174
Location:117 → 270

Anillin; Cell division protein anillin

cl17171
Location:309 → 364

PH-like; Pleckstrin homology-like domain
XM_006505808.3 → XP_006505871.1 rhotekin isoform X3

See identical proteins and their annotated locations for XP_006505871.1

Conserved Domains (3) summary

smart00742
Location:23 → 78

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam08174
Location:104 → 257

Anillin; Cell division protein anillin

cl17171
Location:296 → 351

PH-like; Pleckstrin homology-like domain
XM_006505809.3 → XP_006505872.1 rhotekin isoform X3

See identical proteins and their annotated locations for XP_006505872.1

Conserved Domains (3) summary

smart00742
Location:23 → 78

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam08174
Location:104 → 257

Anillin; Cell division protein anillin

cl17171
Location:296 → 351

PH-like; Pleckstrin homology-like domain
XM_006505811.3 → XP_006505874.1 rhotekin isoform X4

See identical proteins and their annotated locations for XP_006505874.1

Conserved Domains (3) summary

pfam08174
Location:67 → 220

Anillin; Cell division protein anillin

cl00087
Location:1 → 41

HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

cl17171
Location:259 → 314

PH-like; Pleckstrin homology-like domain
XM_030255274.2 → XP_030111134.1 rhotekin isoform X7

Conserved Domains (3) summary

smart00742
Location:23 → 78

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam08174
Location:104 → 257

Anillin; Cell division protein anillin

cl17171
Location:296 → 406

PH-like; Pleckstrin homology-like domain
XM_006505805.4 → XP_006505868.1 rhotekin isoform X1

Conserved Domains (3) summary

smart00742
Location:82 → 135

Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues

pfam08174
Location:161 → 314

Anillin; Cell division protein anillin

cl17171
Location:353 → 408

PH-like; Pleckstrin homology-like domain
XM_006505812.2 → XP_006505875.1 rhotekin isoform X4

See identical proteins and their annotated locations for XP_006505875.1

Conserved Domains (3) summary

pfam08174
Location:67 → 220

Anillin; Cell division protein anillin

cl00087
Location:1 → 41

HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

cl17171
Location:259 → 314

PH-like; Pleckstrin homology-like domain