Nobox NOBOX oogenesis homeobox [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Noboxprovided by MGI
Official Full Name: NOBOX oogenesis homeoboxprovided by MGI
Primary source: MGI:MGI:108011
See related: Ensembl:ENSMUSG00000029736 AllianceGenome:MGI:108011
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OG2; Og2x
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within ovarian follicle development. Located in cytoplasm. Is expressed in several structures, including eye; genitourinary system; heart; liver; and musculoskeletal system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 5. Orthologous to human NOBOX (NOBOX oogenesis homeobox). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward ovary adult (RPKM 3.9) See more
Orthologs: human all
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Genomic context

Location:: 6 B2.1; 6 21.17 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (43280608..43287006, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (43303674..43310072, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The NOBOX protein is expressed throughout oocyte growth in the nucleus of ovarian Non Surrounded Nucleolus and in MII(Non Surrounded Nucleolus) oocytes; beginning with Surrounded Nucleolus oocytes of 61-70 microm, it becomes almost undetectable.
Title: The NOBOX protein becomes undetectable in developmentally competent antral and ovulated oocytes.
These results indicate that premature ovarian failure syndrome in Nobox deficient mice results from the faulty signaling between somatic and germ line components during embryonic development.
Title: Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown.
identified one Nobox DNA-binding element within the Pad6 promoter. findings indicate that Nobox is a critical regulator that orchestrates oocyte-specific genes such as Pad6 during folliculogenesis.
Title: The oocyte-specific transcription factor, Nobox, regulates the expression of Pad6, a peptidylarginine deiminase in the oocyte.
RT-PCR data shows an increase in oogenesis specific gene transcripts (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) between the primordial until the preantral stages, with the exception of the Oogenesin1 transcripts under gonadotropin-induction.
Title: Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.
findings indicate that Nobox is likely an activator of oocyte-specific gene expression
Title: Microarray analyses of newborn mouse ovaries lacking Nobox.
Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development
Title: NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.
NOBOX directly regulates the transcription of Pou5f1 and Gdf9 in oocytes during early folliculogenesis
Title: Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

Nobox (e-PCR), detects polymorphism
- UniSTS:525716

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: homeobox protein NOBOX

Names: OG2 homeobox; homeodomain-containing protein OG-2; newborn ovary homeobox protein; oocyte-specific homeobox protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130869.3 → NP_570939.1 homeobox protein NOBOX

See identical proteins and their annotated locations for NP_570939.1

Status: VALIDATED

Source sequence(s)

AC153885

Consensus CDS

CCDS20093.1

UniProtKB/Swiss-Prot

P70367, Q8VIH1

Related

ENSMUSP00000031749.9, ENSMUST00000031749.16

Conserved Domains (2) summary

COG5576
Location:94 → 213

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:139 → 192

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

43280608..43287006 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255220.1 → XP_030111080.1 homeobox protein NOBOX isoform X1

Conserved Domains (2) summary

COG5576
Location:127 → 246

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:172 → 226

Homeobox; Homeobox domain