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    Catsperg2 cation channel sperm associated auxiliary subunit gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 76718, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Catsperg2provided by MGI
    Official Full Name
    cation channel sperm associated auxiliary subunit gamma 2provided by MGI
    Primary source
    MGI:MGI:1923968
    See related
    Ensembl:ENSMUSG00000049123 AllianceGenome:MGI:1923968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CATSPERG; 1700067C01Rik
    Summary
    Predicted to be involved in cell differentiation and spermatogenesis. Located in motile cilium. Part of CatSper complex. Is expressed in germ cell of testis; seminiferous tubule; spermatid; spermatocyte; and testis. Orthologous to human CATSPERG (cation channel sperm associated auxiliary subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 75.6) See more
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    Genomic context

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    See Catsperg2 in Genome Data Viewer
    Location:
    7 B1; 7 17.2 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29396642..29426474, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29697217..29727049, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930432E11 gene Neighboring gene STARR-seq mESC enhancer starr_18479 Neighboring gene STARR-seq mESC enhancer starr_18480 Neighboring gene predicted gene, 45978 Neighboring gene STARR-seq mESC enhancer starr_18481 Neighboring gene STARR-seq mESC enhancer starr_18484 Neighboring gene STARR-seq mESC enhancer starr_18485 Neighboring gene predicted gene, 23103 Neighboring gene predicted gene, 38983

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Wang H, et al. Biol Reprod, 2009 Sep. PMID 19516020, Free PMC Article
    2. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353
    3. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Chung JJ, et al. Nat Commun, 2011 Jan 11. PMID 21224844, Free PMC Article
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm principal piece IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cation channel sperm-associated auxiliary subunit gamma 2
    Names
    CATSPER gamma subunit protein
    cation channel sperm-associated protein subunit gamma 2
    cation channel, sperm-associated, gamma 2
    catsper channel auxiliary subunit gamma 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029714.4 → NP_083990.2  cation channel sperm-associated auxiliary subunit gamma 2 precursor

      See identical proteins and their annotated locations for NP_083990.2

      Status: VALIDATED

      Source sequence(s)
      AC112789, AK006911, AV277342, BB614579, BU938829, BY724013
      Consensus CDS
      CCDS52173.1
      UniProtKB/Swiss-Prot
      C6KI89
      Related
      ENSMUSP00000052285.4, ENSMUST00000061193.4
      Conserved Domains (1) summary
      pfam15064
      Location:7 → 973
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29396642..29426474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540413.3 → XP_006540476.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X2

      Conserved Domains (1) summary
      pfam15064
      Location:7 → 953
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    2. XM_011250737.2 → XP_011249039.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X4

      Conserved Domains (1) summary
      pfam15064
      Location:7 → 937
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    3. XM_006540414.3 → XP_006540477.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X6

      Conserved Domains (1) summary
      pfam15064
      Location:7 → 943
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    4. XM_011250736.3 → XP_011249038.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X3

      Conserved Domains (1) summary
      pfam15064
      Location:7 → 973
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    5. XM_011250738.3 → XP_011249040.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X5

      Conserved Domains (1) summary
      pfam15064
      Location:7 → 920
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    6. XM_036153550.1 → XP_036009443.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X10

      Conserved Domains (1) summary
      pfam15064
      Location:56 → 753
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    7. XM_006540417.4 → XP_006540480.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X9

      Conserved Domains (1) summary
      pfam15064
      Location:7 → 788
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    8. XM_006540416.4 → XP_006540479.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X7

      Conserved Domains (1) summary
      pfam15064
      Location:7 → 806
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    9. XM_006540412.2 → XP_006540475.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X1

      See identical proteins and their annotated locations for XP_006540475.1

      UniProtKB/Swiss-Prot
      C6KI89
      Conserved Domains (1) summary
      pfam15064
      Location:7 → 973
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    10. XM_017312381.3 → XP_017167870.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X1

      UniProtKB/Swiss-Prot
      C6KI89
      Related
      ENSMUSP00000147099.2, ENSMUST00000209126.2
      Conserved Domains (1) summary
      pfam15064
      Location:7 → 973
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    11. XM_011250739.3 → XP_011249041.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X8

      UniProtKB/TrEMBL
      A0A140LJ05
      Related
      ENSMUSP00000147029.2, ENSMUST00000207115.2
      Conserved Domains (1) summary
      pfam15064
      Location:7 → 973
      CATSPERG; Cation channel sperm-associated protein subunit gamma
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C6KI89.1 GenPept UniProtKB/Swiss-Prot:C6KI89

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