C2cd5 C2 calcium-dependent domain containing 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C2cd5provided by MGI
Official Full Name: C2 calcium-dependent domain containing 5provided by MGI
Primary source: MGI:MGI:1921991
See related: Ensembl:ENSMUSG00000030279 AllianceGenome:MGI:1921991
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDP138; 5730419I09Rik; C030008B15Rik
Summary: Enables calcium ion binding activity. Involved in insulin receptor signaling pathway; positive regulation of D-glucose transmembrane transport; and positive regulation of vesicle fusion. Acts upstream of or within positive regulation of D-glucose import; protein localization to plasma membrane; and vesicle fusion. Located in plasma membrane. Orthologous to human C2CD5 (C2 calcium dependent domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 8.8), CNS E14 (RPKM 8.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 75.13 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (142956646..143045878, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (143010920..143100155, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypothalamic C2CD5 is involved in MC4R endocytosis and regulate bodyweight homeostasis. This suggests that C2CD5 represents a new protein regulated by metabolic cues and involved in metabolic receptor endocytosis. C2CD5 represents a new target and pathway that could be targeted in Obesity.
Title: Hypothalamic C2-domain protein involved in MC4R trafficking and control of energy balance.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of D-glucose import	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of D-glucose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of D-glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: C2 domain-containing protein 5

Names: 138 kDa C2 domain-containing phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109688.2 → NP_001103158.1 C2 domain-containing protein 5 isoform 3

See identical proteins and their annotated locations for NP_001103158.1

Status: VALIDATED

Source sequence(s)

AC127354, AK141590, AK143732, AK162114, AK163233, AU022314, BC053913

Consensus CDS

CCDS51953.1

UniProtKB/TrEMBL

Q3TSE2

Related

ENSMUSP00000084758.5, ENSMUST00000087485.7

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
NM_001286578.1 → NP_001273507.1 C2 domain-containing protein 5 isoform 4

Status: VALIDATED

Source sequence(s)

AC127354, AK029825, AK143732, AK162114, AK163233, AU022314, BC053913

UniProtKB/TrEMBL

Q3TSE2
NM_001362113.1 → NP_001349042.1 C2 domain-containing protein 5 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).

Source sequence(s)

AC122797, AC127354

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
NM_001362114.1 → NP_001349043.1 C2 domain-containing protein 5 isoform 6

Status: VALIDATED

Source sequence(s)

AC122797, AC127354

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
NM_001362115.1 → NP_001349044.1 C2 domain-containing protein 5 isoform 7

Status: VALIDATED

Source sequence(s)

AC122797, AC127354

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
NM_001362116.1 → NP_001349045.1 C2 domain-containing protein 5 isoform 8

Status: VALIDATED

Source sequence(s)

AC122797, AC127354

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
NM_001362117.1 → NP_001349046.1 C2 domain-containing protein 5 isoform 9

Status: VALIDATED

Source sequence(s)

AC122797, AC127354

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
NM_001362118.1 → NP_001349047.1 C2 domain-containing protein 5 isoform 10

Status: VALIDATED

Source sequence(s)

AC122797, AC127354
NM_029081.3 → NP_083357.2 C2 domain-containing protein 5 isoform 1

See identical proteins and their annotated locations for NP_083357.2

Status: VALIDATED

Source sequence(s)

AC127354, AK029825, AK143732, AK162114, AK163233, AU022314, BC053913

Consensus CDS

CCDS51952.1

UniProtKB/Swiss-Prot

Q3TQY6, Q6A052, Q7TPS5, Q80VA1, Q8C0U3, Q8CID5, Q9CS85

UniProtKB/TrEMBL

Q3TSE2

Related

ENSMUSP00000145373.2, ENSMUST00000203187.3

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
NM_029897.2 → NP_084173.1 C2 domain-containing protein 5 isoform 2

See identical proteins and their annotated locations for NP_084173.1

Status: VALIDATED

Source sequence(s)

AC127354, AK143732, AK162114, AU022314, BC053913

Consensus CDS

CCDS51951.1

UniProtKB/TrEMBL

E9Q026, Q3TSE2

Related

ENSMUSP00000127834.2, ENSMUST00000171349.8

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

142956646..143045878 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321797.3 → XP_017177286.1 C2 domain-containing protein 5 isoform X2

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:419 → 457

YbjQ_1; Putative heavy-metal-binding
XM_017321809.3 → XP_017177298.1 C2 domain-containing protein 5 isoform X12

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:408 → 446

YbjQ_1; Putative heavy-metal-binding
XM_036152375.1 → XP_036008268.1 C2 domain-containing protein 5 isoform X9

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
XM_017321799.3 → XP_017177288.1 C2 domain-containing protein 5 isoform X4

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:408 → 446

YbjQ_1; Putative heavy-metal-binding
XM_017321804.3 → XP_017177293.1 C2 domain-containing protein 5 isoform X8

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:430 → 468

YbjQ_1; Putative heavy-metal-binding
XM_017321801.3 → XP_017177290.1 C2 domain-containing protein 5 isoform X6

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:430 → 468

YbjQ_1; Putative heavy-metal-binding
XM_006506997.5 → XP_006507060.1 C2 domain-containing protein 5 isoform X1

See identical proteins and their annotated locations for XP_006507060.1

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:430 → 468

YbjQ_1; Putative heavy-metal-binding
XM_036152385.1 → XP_036008278.1 C2 domain-containing protein 5 isoform X22

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
XM_017321802.3 → XP_017177291.1 C2 domain-containing protein 5 isoform X7

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:388 → 426

YbjQ_1; Putative heavy-metal-binding
XM_036152376.1 → XP_036008269.1 C2 domain-containing protein 5 isoform X11

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
XM_017321798.3 → XP_017177287.1 C2 domain-containing protein 5 isoform X3

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:410 → 448

YbjQ_1; Putative heavy-metal-binding
XM_036152377.1 → XP_036008270.1 C2 domain-containing protein 5 isoform X13

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
XM_017321800.3 → XP_017177289.1 C2 domain-containing protein 5 isoform X5

UniProtKB/TrEMBL

A0A0N4SW93, Q3TSE2

Related

ENSMUSP00000145425.2, ENSMUST00000203673.3

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:399 → 437

YbjQ_1; Putative heavy-metal-binding
XM_017321807.3 → XP_017177296.1 C2 domain-containing protein 5 isoform X10

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (2) summary

cd08688
Location:5 → 114

C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

cl00426
Location:421 → 459

YbjQ_1; Putative heavy-metal-binding
XM_036152380.1 → XP_036008273.1 C2 domain-containing protein 5 isoform X17

UniProtKB/TrEMBL

Q3TSE2
XM_036152379.1 → XP_036008272.1 C2 domain-containing protein 5 isoform X16

UniProtKB/TrEMBL

Q3TSE2
XM_036152378.1 → XP_036008271.1 C2 domain-containing protein 5 isoform X15

UniProtKB/TrEMBL

Q3TSE2
XM_030255649.2 → XP_030111509.1 C2 domain-containing protein 5 isoform X14

UniProtKB/TrEMBL

Q3TSE2

Conserved Domains (1) summary

cl00426
Location:215 → 253

YbjQ_1; Putative heavy-metal-binding
XM_036152384.1 → XP_036008277.1 C2 domain-containing protein 5 isoform X21
XM_036152381.1 → XP_036008274.1 C2 domain-containing protein 5 isoform X18

Conserved Domains (1) summary

cl00426
Location:112 → 150

YbjQ_1; Putative heavy-metal-binding
XM_006507009.5 → XP_006507072.1 C2 domain-containing protein 5 isoform X18
XM_036152382.1 → XP_036008275.1 C2 domain-containing protein 5 isoform X19
XM_036152383.1 → XP_036008276.1 C2 domain-containing protein 5 isoform X20
XM_017321813.3 → XP_017177302.1 C2 domain-containing protein 5 isoform X21