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    Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 330836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc7a6provided by MGI
    Official Full Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 6provided by MGI
    Primary source
    MGI:MGI:2142598
    See related
    Ensembl:ENSMUSG00000031904 AllianceGenome:MGI:2142598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAT3; LAT-2; y+LAT-2
    Summary
    Predicted to enable L-lysine:L-arginine antiporter activity and arginine binding activity. Involved in glycine betaine transport. Predicted to be located in plasma membrane. Is expressed in brain; cumulus oophorus; embryo; gonad; and oocyte. Orthologous to human SLC7A6 (solute carrier family 7 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 13.4), whole brain E14.5 (RPKM 13.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc7a6 in Genome Data Viewer
    Location:
    8 D3; 8 53.1 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106894718..106925346)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106168219..106198714)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene STARR-positive B cell enhancer ABC_E9739 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr8:108674075-108674376 Neighboring gene phospholipase A2, group XV Neighboring gene solute carrier family 7, member 6 opposite strand Neighboring gene protein arginine N-methyltransferase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2. Hinz KM, et al. Mol Endocrinol, 2015 Jun. PMID 25945809, Free PMC Article
    2. Uptake of betaine into mouse cumulus-oocyte complexes via the SLC7A6 isoform of y+L transporter. Corbett HE, et al. Biol Reprod, 2014 Apr. PMID 24599290
    3. Amino acid transporter LAT3 is required for podocyte development and function. Sekine Y, et al. J Am Soc Nephrol, 2009 Jul. PMID 19443642, Free PMC Article
    4. Relationship of quantitative reverse transcription polymerase chain reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome identifies mouse preimplantation embryo reference genes†. Tscherner AK, et al. Biol Reprod, 2023 Nov 15. PMID 37669129, Free PMC Article
    5. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data help to elucidate the molecular mechanisms and role of Lat2 in thyroid hormone transport.
      Title: Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2.
    2. Both transcripts and protein of one y+L isoform, SLC7A6 (y+LAT2), are present in cumulus oocyte complexes, with little or no expression in isolated germinal vesicle (GV)-stage oocytes, MII eggs, or one-cell embryos.
      Title: Uptake of betaine into mouse cumulus-oocyte complexes via the SLC7A6 isoform of y+L transporter.
    3. LAT3 may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton.
      Title: Amino acid transporter LAT3 is required for podocyte development and function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-arginine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-lysine:L-arginine antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-lysine:L-arginine antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables arginine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arginine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables basic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-arginine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-leucine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine betaine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ornithine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ornithine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Y+L amino acid transporter 2
    Names
    solute carriersolute carrier family 7 (cationic amino acid transporter, y+ system), member 6
    y(+)L-type amino acid transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357381.1 → NP_001344310.1  Y+L amino acid transporter 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC133195
      Consensus CDS
      CCDS22631.1
      UniProtKB/Swiss-Prot
      Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    2. NM_001357382.1 → NP_001344311.1  Y+L amino acid transporter 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI118666, AK030762, BB398929, BB855052, CF725752
      Conserved Domains (1) summary
      cl26159
      Location:1 → 293
      AA_permease_2; Amino acid permease

    3. NM_178798.4 → NP_848913.1  Y+L amino acid transporter 2 isoform 1

      See identical proteins and their annotated locations for NP_848913.1

      Status: VALIDATED

      Source sequence(s)
      AI118666, AK053899, BB398929, BB855052, CF725752
      Consensus CDS
      CCDS22631.1
      UniProtKB/Swiss-Prot
      Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
      Related
      ENSMUSP00000034378.4, ENSMUST00000034378.5
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    RNA

    1. NR_151676.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC133195, AI118666, AK046548, AK049478, BB398929, BB855052, CF725752

    2. NR_151677.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC133195

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106894718..106925346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154138.1 → XP_036010031.1  Y+L amino acid transporter 2 isoform X3

      UniProtKB/Swiss-Prot
      Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    2. XM_006531138.5 → XP_006531201.1  Y+L amino acid transporter 2 isoform X3

      See identical proteins and their annotated locations for XP_006531201.1

      UniProtKB/Swiss-Prot
      Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    3. XM_006531136.4 → XP_006531199.1  Y+L amino acid transporter 2 isoform X2

      Conserved Domains (1) summary
      TIGR00911
      Location:30 → 514
      2A0308; L-type amino acid transporter

    4. XM_030243635.2 → XP_030099495.1  Y+L amino acid transporter 2 isoform X3

      UniProtKB/Swiss-Prot
      Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    5. XM_017312868.3 → XP_017168357.1  Y+L amino acid transporter 2 isoform X3

      UniProtKB/Swiss-Prot
      Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    6. XM_030243634.2 → XP_030099494.1  Y+L amino acid transporter 2 isoform X3

      UniProtKB/Swiss-Prot
      Q3TMY5, Q3U084, Q6ZQF5, Q8BGK6, Q8CFY3
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    7. XM_006531135.5 → XP_006531198.1  Y+L amino acid transporter 2 isoform X1

      Conserved Domains (1) summary
      TIGR00911
      Location:34 → 518
      2A0308; L-type amino acid transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGK6.1 GenPept UniProtKB/Swiss-Prot:Q8BGK6

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