Zfyve1 zinc finger, FYVE domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfyve1provided by MGI
Official Full Name: zinc finger, FYVE domain containing 1provided by MGI
Primary source: MGI:MGI:3026685
See related: Ensembl:ENSMUSG00000042628 AllianceGenome:MGI:3026685
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DFCP1; TAFF1; ZNFN2A1; mKIAA1589; G630053K23
Summary: Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in lipid droplet formation. Located in several cellular components, including Golgi apparatus; lipid droplet; and mitochondrion. Orthologous to human ZFYVE1 (zinc finger FYVE-type containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 23.4), liver adult (RPKM 10.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 38.76 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (83593330..83679289, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (83546556..83597245, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
Title: The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
ZFYVE1 acts as a specific negative regulator of MDA5-mediated innate immune responses by inhibiting its ligand binding and oligomerization.
Title: ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response.
Endogenous DFCP1 was preferentially associated with mitochondria rather than with the Golgi apparatus or the endoplasmic reticulum in Hela cells.
Title: Cellular localization and tissue distribution of endogenous DFCP1 protein.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid droplet formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet formation	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by host of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral genome replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	ISS Inferred from Sequence or Structural Similarity more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extrinsic component of omegasome membrane	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of omegasome membrane	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in omegasome	ISO Inferred from Sequence Orthology more info	PubMed
located_in omegasome	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info	PubMed
located_in phagophore assembly site	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger FYVE domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359166.1 → NP_001346095.1 zinc finger FYVE domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AA222714, AA422700, AC055772, AK139825, BB398888, BC050015, BY147113, BY256667, CF165708, CJ103131, CO043975

Consensus CDS

CCDS26028.1

UniProtKB/Swiss-Prot

Q3TC20, Q810J8

UniProtKB/TrEMBL

Q3UT32

Conserved Domains (5) summary

cd01851
Location:174 → 410

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd15734
Location:711 → 771

FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins

cl28890
Location:594 → 655

FYVE_like_SF; FYVE domain like superfamily

cd19819
Location:16 → 63

Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

cd19820
Location:69 → 121

Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
NM_001359167.1 → NP_001346096.1 zinc finger FYVE domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AA422700, AC055772, AC139382, AK090334

Consensus CDS

CCDS26028.1

UniProtKB/Swiss-Prot

Q3TC20, Q810J8

UniProtKB/TrEMBL

Q3UT32

Related

ENSMUSP00000152501.2, ENSMUST00000221919.2

Conserved Domains (5) summary

cd01851
Location:174 → 410

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd15734
Location:711 → 771

FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins

cl28890
Location:594 → 655

FYVE_like_SF; FYVE domain like superfamily

cd19819
Location:16 → 63

Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

cd19820
Location:69 → 121

Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
NM_001359168.1 → NP_001346097.1 zinc finger FYVE domain-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AA422700, AC139382, AK139825

Conserved Domains (2) summary

cd15734
Location:296 → 356

FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins

cl28890
Location:179 → 240

FYVE_like_SF; FYVE domain like superfamily
NM_001422984.1 → NP_001409913.1 zinc finger FYVE domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC055772, AC139382

UniProtKB/Swiss-Prot

Q3TC20, Q810J8
NM_183154.4 → NP_898977.2 zinc finger FYVE domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_898977.2

Status: VALIDATED

Source sequence(s)

AA422700, AC055772, AC139382, BC050015

Consensus CDS

CCDS26028.1

UniProtKB/Swiss-Prot

Q3TC20, Q810J8

UniProtKB/TrEMBL

Q3UT32

Related

ENSMUSP00000042224.5, ENSMUST00000048319.6

Conserved Domains (5) summary

cd01851
Location:174 → 410

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd15734
Location:711 → 771

FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins

cl28890
Location:594 → 655

FYVE_like_SF; FYVE domain like superfamily

cd19819
Location:16 → 63

Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

cd19820
Location:69 → 121

Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

RNA

NR_186678.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC055772, AC139382

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

83593330..83679289 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157320.1 → XP_036013213.1 zinc finger FYVE domain-containing protein 1 isoform X2

Conserved Domains (2) summary

cd15734
Location:296 → 356

FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins

cl28890
Location:179 → 240

FYVE_like_SF; FYVE domain like superfamily
XM_006515690.5 → XP_006515753.1 zinc finger FYVE domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006515753.1

UniProtKB/Swiss-Prot

Q3TC20, Q810J8

UniProtKB/TrEMBL

Q3UT32

Conserved Domains (5) summary

cd01851
Location:174 → 410

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd15734
Location:711 → 771

FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins

cl28890
Location:594 → 655

FYVE_like_SF; FYVE domain like superfamily

cd19819
Location:16 → 63

Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

cd19820
Location:69 → 121

Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
XM_036157321.1 → XP_036013214.1 zinc finger FYVE domain-containing protein 1 isoform X2

Conserved Domains (2) summary

cd15734
Location:296 → 356

FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins

cl28890
Location:179 → 240

FYVE_like_SF; FYVE domain like superfamily
XM_030246658.2 → XP_030102518.1 zinc finger FYVE domain-containing protein 1 isoform X2

Conserved Domains (2) summary

cd15734
Location:296 → 356

FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins

cl28890
Location:179 → 240

FYVE_like_SF; FYVE domain like superfamily