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    Spry3 sprouty RTK signaling antagonist 3 [ Mus musculus (house mouse) ]

    Gene ID: 236576, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spry3provided by MGI
    Official Full Name
    sprouty RTK signaling antagonist 3provided by MGI
    Primary source
    MGI:MGI:1345188
    See related
    AllianceGenome:MGI:1345188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm391; Gm1409; sprouty3
    Summary
    Involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of neuron projection arborization. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Is expressed in brain; head; pancreas; and testis. Orthologous to human SPRY3 (sprouty RTK signaling antagonist 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Spry3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X Unlocalized Scaffold NT_165789.3 (196343..206844, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X Unlocalized Scaffold NT_165789.2 (101352..110912, complement)

    NT_165789.3Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 7 Neighboring gene uncharacterized LOC115489310 Neighboring gene trimethyllysine hydroxylase, epsilon Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 pseudogene Neighboring gene zinc finger protein 24 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of neuron projection arborization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein sprouty homolog 3
    Names
    sprouty homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030293.3NP_001025464.1  protein sprouty homolog 3

      See identical proteins and their annotated locations for NP_001025464.1

      Status: VALIDATED

      Source sequence(s)
      CAAA01019125, MG954267
      UniProtKB/Swiss-Prot
      Q3UUD2
      Conserved Domains (1) summary
      pfam05210
      Location:152253
      Sprouty; Sprouty protein (Spry)
    2. NM_001401849.1NP_001388778.1  protein sprouty homolog 3

      Status: VALIDATED

      Source sequence(s)
      CAAA01019125, MG954267
      UniProtKB/Swiss-Prot
      Q3UUD2
    3. NM_001401850.1NP_001388779.1  protein sprouty homolog 3

      Status: VALIDATED

      Source sequence(s)
      CAAA01019125, MG954267
      UniProtKB/Swiss-Prot
      Q3UUD2
    4. NM_001401851.1NP_001388780.1  protein sprouty homolog 3

      Status: VALIDATED

      Source sequence(s)
      CAAA01019125, CAAA01122338, MG954267
      UniProtKB/Swiss-Prot
      Q3UUD2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NT_165789.3 Reference GRCm39 C57BL/6J

      Range
      196343..206844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)