Zdhhc3 zinc finger, DHHC domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zdhhc3provided by MGI
Official Full Name: zinc finger, DHHC domain containing 3provided by MGI
Primary source: MGI:MGI:1926134
See related: Ensembl:ENSMUSG00000025786 AllianceGenome:MGI:1926134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GODZ; DHHC-3; Gramp1; Zfp373; 1110020O22Rik; 1810006O10Rik; 2210017C02Rik
Summary: Enables protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; positive regulation of GABAergic synaptic transmission; and positive regulation of receptor localization to synapse. Acts upstream of or within protein targeting. Located in Golgi apparatus. Is expressed in central nervous system; early conceptus; genitourinary system; and ileum. Orthologous to human ZDHHC3 (zinc finger DHHC-type palmitoyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 19.6), ovary adult (RPKM 12.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 73.66 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (122895224..122942269, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (123066159..123113194, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption.
Title: IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption.
Absence of zinc finger protein GODZ affects primary and latent infection, as well as reactivation, in ocularly infected mice. The reduced virus infectivity is due to the absence of the GODZ interaction with HSV-1 UL20. These results strongly suggest that binding of UL20 to GODZ promotes virus infectivity in vitro and viral pathogenesis in vivo.
Title: The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection.
Loss of GODZ expression is associated with reduced Palmitoylation of GABA type A receptors .
Title: Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice.
Findings highlight that FGFR- and Src-mediated tyrosine phosphorylation of ZDHHC3 modulates ZDHHC3 enzymatic activity and plays a role in neuronal morphogenesis.
Title: ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.
coordination of zinc ions by cysteine residues within the cysteine-rich domain is required for the structural integrity of DHHC3
Title: The Cysteine-rich Domain of the DHHC3 Palmitoyltransferase Is Palmitoylated and Contains Tightly Bound Zinc.
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Data conclude that GODZ encodes a Ca(2+) transport protein in addition to its ability to palmitoylate protein substrates.
Title: Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport.
GODZ-mediated palmitoylation is a novel posttranslational modification that is selective for gamma-subunit-containing GABA(A) receptor subtypes, a mechanism that may be important for regulated trafficking of these receptors in the secretory pathway.
Title: The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ.
GODZ-mediated palmitoylation of GABA(A) receptor gamma 2 subunit, and possibly other substrates, contributes selectively to the formation and normal function of GABAergic inhibitory synapses.
Title: GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses.
identified a novel Golgi apparatus-specific protein, designated as GODZ, which may play a role in membrane protein trafficking (GODZ)
Title: Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236294

NoName (e-PCR)
- UniSTS:236295

BE688926 (e-PCR)
- UniSTS:208470

BF416391 (e-PCR)
- UniSTS:249267

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-cysteine S-myristoyltransferase activity	IC Inferred by Curator more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IC Inferred by Curator more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-cysteine S-stearoyltransferase activity	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in TRAIL-activated apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in TRAIL-activated apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipoprotein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein localization to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-L-cysteine S-palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to photoreceptor outer segment	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC3

Names: GABA-A receptor-associated membrane protein 1; acyltransferase ZDHHC3; golgi-specific DHHC zinc finger protein; zinc finger DHHC domain-containing protein 3

NP_001359467.1

EC 2.3.1.225

NP_001359468.1

EC 2.3.1.225

NP_001359469.1

EC 2.3.1.225

NP_001359470.1

EC 2.3.1.225

NP_001359471.1

EC 2.3.1.225

NP_001359472.1

EC 2.3.1.225

NP_001359473.1

EC 2.3.1.225

NP_001359475.1

EC 2.3.1.225

NP_001359476.1

EC 2.3.1.225

NP_001359477.1

EC 2.3.1.225

NP_001359478.1

EC 2.3.1.225

NP_001359479.1

EC 2.3.1.225

NP_001359480.1

EC 2.3.1.225

NP_001359481.1

EC 2.3.1.225

NP_001359482.1

EC 2.3.1.225

NP_081193.2

EC 2.3.1.225

XP_006512313.1

EC 2.3.1.225

XP_006512314.1

EC 2.3.1.225

XP_006512318.1

EC 2.3.1.225

XP_030100417.1

EC 2.3.1.225

XP_036011128.1

EC 2.3.1.225

XP_036011129.1

EC 2.3.1.225

XP_036011130.1

EC 2.3.1.225

XP_036011132.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372538.1 → NP_001359467.1 palmitoyltransferase ZDHHC3 isoform 1

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Consensus CDS

CCDS90691.1

UniProtKB/TrEMBL

A0A571BEV7

Related

ENSMUSP00000158842.2, ENSMUST00000238520.2

Conserved Domains (1) summary

pfam01529
Location:128 → 253

DHHC; DHHC palmitoyltransferase
NM_001372539.1 → NP_001359468.1 palmitoyltransferase ZDHHC3 isoform 2

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

UniProtKB/Swiss-Prot

Q6EMK3, Q8R173

Conserved Domains (1) summary

pfam01529
Location:128 → 255

DHHC; DHHC palmitoyltransferase
NM_001372540.1 → NP_001359469.1 palmitoyltransferase ZDHHC3 isoform 3

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:127 → 254

DHHC; DHHC palmitoyltransferase
NM_001372541.1 → NP_001359470.1 palmitoyltransferase ZDHHC3 isoform 4

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:121 → 232

DHHC; DHHC palmitoyltransferase
NM_001372542.1 → NP_001359471.1 palmitoyltransferase ZDHHC3 isoform 5

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:33 → 160

DHHC; DHHC palmitoyltransferase
NM_001372543.1 → NP_001359472.1 palmitoyltransferase ZDHHC3 isoform 6

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:30 → 157

DHHC; DHHC palmitoyltransferase
NM_001372544.1 → NP_001359473.1 palmitoyltransferase ZDHHC3 isoform 6

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:30 → 157

DHHC; DHHC palmitoyltransferase
NM_001372546.1 → NP_001359475.1 palmitoyltransferase ZDHHC3 isoform 7

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:1 → 101

DHHC; DHHC palmitoyltransferase
NM_001372547.1 → NP_001359476.1 palmitoyltransferase ZDHHC3 isoform 7

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:1 → 101

DHHC; DHHC palmitoyltransferase
NM_001372548.1 → NP_001359477.1 palmitoyltransferase ZDHHC3 isoform 8

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:1 → 103

DHHC; DHHC palmitoyltransferase
NM_001372549.1 → NP_001359478.1 palmitoyltransferase ZDHHC3 isoform 8

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:1 → 103

DHHC; DHHC palmitoyltransferase
NM_001372550.1 → NP_001359479.1 palmitoyltransferase ZDHHC3 isoform 8

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:1 → 103

DHHC; DHHC palmitoyltransferase
NM_001372551.1 → NP_001359480.1 palmitoyltransferase ZDHHC3 isoform 8

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:1 → 103

DHHC; DHHC palmitoyltransferase
NM_001372552.1 → NP_001359481.1 palmitoyltransferase ZDHHC3 isoform 8

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:1 → 103

DHHC; DHHC palmitoyltransferase
NM_001372553.1 → NP_001359482.1 palmitoyltransferase ZDHHC3 isoform 8

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Conserved Domains (1) summary

pfam01529
Location:1 → 103

DHHC; DHHC palmitoyltransferase
NM_026917.6 → NP_081193.2 palmitoyltransferase ZDHHC3 isoform 2

See identical proteins and their annotated locations for NP_081193.2

Status: VALIDATED

Source sequence(s)

AC133650, AC134248

Consensus CDS

CCDS23654.1

UniProtKB/Swiss-Prot

Q6EMK3, Q8R173

Related

ENSMUSP00000117392.2, ENSMUST00000147563.9

Conserved Domains (1) summary

pfam01529
Location:128 → 255

DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

122895224..122942269 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512251.3 → XP_006512314.1 palmitoyltransferase ZDHHC3 isoform X2

Conserved Domains (1) summary

pfam01529
Location:33 → 158

DHHC; DHHC palmitoyltransferase
XM_036155236.1 → XP_036011129.1 palmitoyltransferase ZDHHC3 isoform X3

Conserved Domains (1) summary

pfam01529
Location:30 → 155

DHHC; DHHC palmitoyltransferase
XM_036155239.1 → XP_036011132.1 palmitoyltransferase ZDHHC3 isoform X6

Conserved Domains (1) summary

pfam01529
Location:1 → 101

DHHC; DHHC palmitoyltransferase
XM_006512250.4 → XP_006512313.1 palmitoyltransferase ZDHHC3 isoform X1

Conserved Domains (1) summary

pfam01529
Location:113 → 230

DHHC; DHHC palmitoyltransferase
XM_036155235.1 → XP_036011128.1 palmitoyltransferase ZDHHC3 isoform X2

Conserved Domains (1) summary

pfam01529
Location:33 → 158

DHHC; DHHC palmitoyltransferase
XM_030244557.2 → XP_030100417.1 palmitoyltransferase ZDHHC3 isoform X4

Conserved Domains (1) summary

pfam01529
Location:33 → 160

DHHC; DHHC palmitoyltransferase
XM_006512255.5 → XP_006512318.1 palmitoyltransferase ZDHHC3 isoform X7
XM_036155237.1 → XP_036011130.1 palmitoyltransferase ZDHHC3 isoform X5