Spx spexin hormone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spxprovided by MGI
Official Full Name: spexin hormoneprovided by MGI
Primary source: MGI:MGI:2442262
See related: Ensembl:ENSMUSG00000071112 AllianceGenome:MGI:2442262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Npq; B230216G23Rik
Summary: Predicted to enable neuropeptide hormone activity; type 2 galanin receptor binding activity; and type 3 galanin receptor binding activity. Involved in long-chain fatty acid import into cell and negative regulation of appetite. Predicted to be located in dense core granule. Predicted to be active in cytoplasm and extracellular space. Is expressed in esophagus and stomach fundus submucosa. Orthologous to human SPX (spexin hormone). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E14 (RPKM 1.9), CNS E18 (RPKM 1.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G2; 6 74.03 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (142359114..142365466)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (142413388..142419740)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2.
Title: Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2.
Mouse Spexin: (III) Differential Regulation by Glucose and Insulin in Glandular Stomach and Functional Implication in Feeding Control.
Title: Mouse Spexin: (III) Differential Regulation by Glucose and Insulin in Glandular Stomach and Functional Implication in Feeding Control.
Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons.
Title: Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons.
Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for transcriptional regulation of spexin gene expression by corticotropin releasing factor.
Title: Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for transcriptional regulation of spexin gene expression by corticotropin releasing factor.
SPX is a novel regulator of lipid metabolism in murine 3T3-L1 and human adipocytes.
Title: Spexin: A novel regulator of adipogenesis and fat tissue metabolism.
Spexin is a novel hormone involved in weight regulation, with potential for obesity therapy.
Title: Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity.
newly identified peptides derived from the NPQ/spexin precursor contribute to CNS-mediated control of arterial blood pressure and salt and water balance and modulate nociceptive responses
Title: Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables type 2 galanin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 2 galanin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables type 3 galanin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 3 galanin receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in long-chain fatty acid import into cell	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of renal sodium excretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of renal sodium excretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gastro-intestinal system smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gastro-intestinal system smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gastro-intestinal system smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in regulation of sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dense core granule	ISO Inferred from Sequence Orthology more info
located_in dense core granule	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spexin

Names: neuropeptide Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242345.1 → NP_001229274.1 spexin isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC142413, AK043509, AK045625, BG092156

Consensus CDS

CCDS85181.1

UniProtKB/TrEMBL

A0A1C7CYU9

Related

ENSMUSP00000118062.5, ENSMUST00000126521.9

Conserved Domains (1) summary

pfam15171
Location:27 → 118

Spexin; Neuropeptide secretory protein family, NPQ, spexin
NM_001369015.1 → NP_001355944.1 spexin isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC142413

Consensus CDS

CCDS90134.1

UniProtKB/Swiss-Prot

D3Z752

Related

ENSMUSP00000147302.2, ENSMUST00000211094.2

Conserved Domains (1) summary

pfam15171
Location:27 → 116

Spexin; Neuropeptide secretory protein family, NPQ, spexin