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    Rnf122 ring finger protein 122 [ Mus musculus (house mouse) ]

    Gene ID: 68867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf122provided by MGI
    Official Full Name
    ring finger protein 122provided by MGI
    Primary source
    MGI:MGI:1916117
    See related
    Ensembl:ENSMUSG00000039328 AllianceGenome:MGI:1916117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110063C11Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of mitochondrial membrane potential; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human RNF122 (ring finger protein 122). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 11.2), CNS E11.5 (RPKM 10.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf122 in Genome Data Viewer
    Location:
    8 A3; 8 17.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (31601855..31623346)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (31111827..31133318)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 26 Neighboring gene STARR-positive B cell enhancer ABC_E4995 Neighboring gene predicted gene, 40484 Neighboring gene STARR-positive B cell enhancer ABC_E2861 Neighboring gene STARR-positive B cell enhancer ABC_E557 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene TELO2 interacting protein 2 Neighboring gene MAK16 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Wang W, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27506794, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF122 suppresses antiviral type I interferon production by targeting RIG-I caspase activation and recruitment domains to mediate RIG-I degradation.
      Title: RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 122
    Names
    ring finger protein 122 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368373.1 → NP_001355302.1  RING finger protein 122 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109163

    2. NM_001368374.1 → NP_001355303.1  RING finger protein 122 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109163

    3. NM_001368375.1 → NP_001355304.1  RING finger protein 122 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109163
      Consensus CDS
      CCDS90381.1
      UniProtKB/Swiss-Prot
      Q80VA7, Q8BGD3, Q8BP31
      Related
      ENSMUSP00000150893.2, ENSMUST00000217278.2
      Conserved Domains (1) summary
      cd16469
      Location:91 → 137
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    4. NM_175136.3 → NP_780345.1  RING finger protein 122 isoform 4

      See identical proteins and their annotated locations for NP_780345.1

      Status: VALIDATED

      Source sequence(s)
      AC109163
      Consensus CDS
      CCDS22220.1
      UniProtKB/TrEMBL
      A0A0R4J0G8
      Related
      ENSMUSP00000040478.8, ENSMUST00000046941.8
      Conserved Domains (1) summary
      cd16469
      Location:91 → 136
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      31601855..31623346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BP31.1 GenPept UniProtKB/Swiss-Prot:Q8BP31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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