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    Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [ Mus musculus (house mouse) ]

    Gene ID: 22123, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Psmd3provided by MGI
    Official Full Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 3provided by MGI
    Primary source
    MGI:MGI:98858
    See related
    Ensembl:ENSMUSG00000017221 AllianceGenome:MGI:98858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psd3; AntP91a; Tstap91a; D11Bwg1349e
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Orthologous to human PSMD3 (proteasome 26S subunit, non-ATPase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 118.0), ovary adult (RPKM 104.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psmd3 in Genome Data Viewer
    Location:
    11 D; 11 62.39 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98573380..98586804)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98682554..98695978)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene gasdermin A2 Neighboring gene STARR-positive B cell enhancer ABC_E7059 Neighboring gene gasdermin A Neighboring gene STARR-seq mESC enhancer starr_30673 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98543708-98543891 Neighboring gene predicted gene, 38985 Neighboring gene colony stimulating factor 3 (granulocyte) Neighboring gene mediator complex subunit 24 Neighboring gene predicted gene, 22059

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation. De Plaen E, et al. Proc Natl Acad Sci U S A, 1988 Apr. PMID 3127830, Free PMC Article
    2. Structure of the gene of tum- transplantation antigen P35B: presence of a point mutation in the antigenic allele. Szikora JP, et al. EMBO J, 1990 Apr. PMID 2108859, Free PMC Article
    3. Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. I. Rejection by syngeneic mice. Uyttenhove C, et al. J Exp Med, 1980 Nov 1. PMID 6776226, Free PMC Article
    4. Structure of the gene of tum- transplantation antigen P91A: the mutated exon encodes a peptide recognized with Ld by cytolytic T cells. Lurquin C, et al. Cell, 1989 Jul 28. PMID 2568889
    5. Puromycin-sensitive aminopeptidase gene (Psa) maps to mouse chromosome 11. Osada T, et al. Genomics, 1999 Mar 15. PMID 10087210

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome accessory complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 3
    Names
    26S proteasome regulatory subunit RPN3
    26S proteasome regulatory subunit S3
    proteasome subunit p58
    tissue specific transplantation antigen P91A
    transplantation antigen P91A
    tum-P91A antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009439.1 → NP_033465.1  26S proteasome non-ATPase regulatory subunit 3

      See identical proteins and their annotated locations for NP_033465.1

      Status: VALIDATED

      Source sequence(s)
      BC003197
      Consensus CDS
      CCDS25359.1
      UniProtKB/Swiss-Prot
      P14685, Q3TP95, Q99LL7
      UniProtKB/TrEMBL
      Q8BK46
      Related
      ENSMUSP00000017365.9, ENSMUST00000017365.15
      Conserved Domains (2) summary
      pfam01399
      Location:354 → 458
      PCI; PCI domain
      pfam08375
      Location:461 → 519
      Rpn3_C; Proteasome regulatory subunit C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98573380..98586804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14685.3 GenPept UniProtKB/Swiss-Prot:P14685

    Gene LinkOut

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