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    Trim21 tripartite motif-containing 21 [ Mus musculus (house mouse) ]

    Gene ID: 20821, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim21provided by MGI
    Official Full Name
    tripartite motif-containing 21provided by MGI
    Primary source
    MGI:MGI:106657
    See related
    Ensembl:ENSMUSG00000030966 AllianceGenome:MGI:106657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ro52; Ssa1
    Summary
    Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; protein ubiquitination; and regulation of DNA-binding transcription factor activity. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; retina; and thymus primordium. Orthologous to human TRIM21 (tripartite motif containing 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 5.4), bladder adult (RPKM 4.4) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Trim21 in Genome Data Viewer
    Location:
    7 E3; 7 54.76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (102207127..102214689, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102557920..102565482, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 4I Neighboring gene olfactory receptor family 52 subfamily B member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr7:109713863-109714163 Neighboring gene predicted gene 5339 Neighboring gene olfactory receptor family 51 subfamily R member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K27-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to type II interferon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stress granule disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress granule disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM21
    Names
    52 kDa Ro protein
    52 kDa ribonucleoprotein autoantigen Ro/SS-A
    52kD Ro/SSA autoantigen
    RING-type E3 ubiquitin transferase TRIM21
    SS-A
    Sjogren syndrome antigen A1
    ro(SS-A)
    sjoegren syndrome type A antigen
    tripartite motif protein 21
    tripartite motif-containing protein 21
    NP_001076021.1
    NP_033303.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082552.2NP_001076021.1  E3 ubiquitin-protein ligase TRIM21

      See identical proteins and their annotated locations for NP_001076021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' non-coding region, hence, has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK150484, AK152619, BB681113, CJ051157
      Consensus CDS
      CCDS40051.1
      UniProtKB/TrEMBL
      Q3U7K7, Q3UCL2
      Related
      ENSMUSP00000102526.2, ENSMUST00000106913.3
      Conserved Domains (4) summary
      cd00021
      Location:86124
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:1154
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13094
      Location:181265
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
      cd12900
      Location:283460
      SPRY_PRY_TRIM21; PRY/SPRY domain in tripartite motif-binding protein 21 (TRIM21) also known as 52kD Ribonucleoprotein Autoantigen (Ro52)
    2. NM_009277.4NP_033303.3  E3 ubiquitin-protein ligase TRIM21

      See identical proteins and their annotated locations for NP_033303.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK171489, BB681113, CJ051157
      Consensus CDS
      CCDS40051.1
      UniProtKB/TrEMBL
      Q3U7K7, Q3UCL2
      Related
      ENSMUSP00000033264.5, ENSMUST00000033264.12
      Conserved Domains (4) summary
      cd00021
      Location:86124
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:1154
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13094
      Location:181265
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
      cd12900
      Location:283460
      SPRY_PRY_TRIM21; PRY/SPRY domain in tripartite motif-binding protein 21 (TRIM21) also known as 52kD Ribonucleoprotein Autoantigen (Ro52)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      102207127..102214689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)