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    S100a5 S100 calcium binding protein A5 [ Mus musculus (house mouse) ]

    Gene ID: 20199, updated on 27-Nov-2024

    Summary

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    Official Symbol
    S100a5provided by MGI
    Official Full Name
    S100 calcium binding protein A5provided by MGI
    Primary source
    MGI:MGI:1338915
    See related
    Ensembl:ENSMUSG00000001023 AllianceGenome:MGI:1338915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S100D9
    Summary
    Predicted to enable calcium-dependent protein binding activity; metal ion binding activity; and protein homodimerization activity. Located in neuronal cell body. Orthologous to human S100A5 (S100 calcium binding protein A5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward frontal lobe adult (RPKM 22.2) See more
    Orthologs
    human all
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    Genomic context

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    See S100a5 in Genome Data Viewer
    Location:
    3 F1; 3 39.27 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90513787..90519091)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90606480..90611784)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A3 Neighboring gene STARR-seq mESC enhancer starr_08292 Neighboring gene S100 calcium binding protein A2 Neighboring gene S100 calcium binding protein A4 Neighboring gene STARR-positive B cell enhancer ABC_E6073 Neighboring gene predicted gene, 57853 Neighboring gene S100 calcium binding protein A6 (calcyclin) Neighboring gene STARR-seq mESC enhancer starr_08293 Neighboring gene predicted gene, 19739

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activity-dependent genes in mouse olfactory sensory neurons. Fischl AM, et al. Chem Senses, 2014 Jun. PMID 24692514, Free PMC Article
    2. In vivo identification of eugenol-responsive and muscone-responsive mouse odorant receptors. McClintock TS, et al. J Neurosci, 2014 Nov 19. PMID 25411495, Free PMC Article
    3. Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Tadenev AL, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21646512, Free PMC Article
    4. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Donato R. Biochim Biophys Acta, 1999 Jul 8. PMID 10395934
    5. Clustered organization of S100 genes in human and mouse. Ridinger K, et al. Biochim Biophys Acta, 1998 Dec 10. PMID 9920416

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein S100-A5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410573.1 → NP_001397502.1  protein S100-A5

      Status: VALIDATED

      Source sequence(s)
      AC160552
      UniProtKB/Swiss-Prot
      O88945, P63084, P82540
      UniProtKB/TrEMBL
      Q149U2

    2. NM_001410574.1 → NP_001397503.1  protein S100-A5

      Status: VALIDATED

      Source sequence(s)
      AC160552
      UniProtKB/Swiss-Prot
      O88945, P63084, P82540
      UniProtKB/TrEMBL
      Q149U2

    3. NM_001410575.1 → NP_001397504.1  protein S100-A5

      Status: VALIDATED

      Source sequence(s)
      AC160552
      UniProtKB/Swiss-Prot
      O88945, P63084, P82540
      UniProtKB/TrEMBL
      Q149U2

    4. NM_001410576.1 → NP_001397505.1  protein S100-A5

      Status: VALIDATED

      Source sequence(s)
      AC160552
      UniProtKB/Swiss-Prot
      O88945, P63084, P82540
      UniProtKB/TrEMBL
      Q149U2

    5. NM_011312.3 → NP_035442.1  protein S100-A5

      See identical proteins and their annotated locations for NP_035442.1

      Status: VALIDATED

      Source sequence(s)
      AC160552
      Consensus CDS
      CCDS38505.1
      UniProtKB/Swiss-Prot
      O88945, P63084, P82540
      UniProtKB/TrEMBL
      Q149U2
      Related
      ENSMUSP00000102952.2, ENSMUST00000107329.8
      Conserved Domains (1) summary
      cd00213
      Location:3 → 88
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90513787..90519091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162969.1 → XP_036018862.1  protein S100-A5 isoform X1

      UniProtKB/Swiss-Prot
      O88945, P63084, P82540
      UniProtKB/TrEMBL
      Q149U2
      Conserved Domains (1) summary
      cd00213
      Location:3 → 88
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

    2. XM_036162970.1 → XP_036018863.1  protein S100-A5 isoform X1

      UniProtKB/Swiss-Prot
      O88945, P63084, P82540
      UniProtKB/TrEMBL
      Q149U2
      Related
      ENSMUSP00000001049.5, ENSMUST00000001049.5
      Conserved Domains (1) summary
      cd00213
      Location:3 → 88
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63084.1 GenPept UniProtKB/Swiss-Prot:P63084

    Gene LinkOut

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