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    Spcs3 signal peptidase complex subunit 3 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 76687, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spcs3provided by MGI
    Official Full Name
    signal peptidase complex subunit 3 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1923937
    See related
    Ensembl:ENSMUSG00000054408 AllianceGenome:MGI:1923937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPC22/23; 1810011E08Rik
    Summary
    Predicted to be involved in protein targeting to ER; signal peptide processing; and viral protein processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Is expressed in alimentary system and liver. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 14.6), liver E14 (RPKM 13.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Spcs3 in Genome Data Viewer
    Location:
    8 B1.3; 8 29.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (54973468..54983033, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (54520433..54529998, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein C12orf41 homolog Neighboring gene STARR-seq mESC enhancer starr_21493 Neighboring gene predicted gene, 33153 Neighboring gene vascular endothelial growth factor C Neighboring gene STARR-seq mESC enhancer starr_21496 Neighboring gene STARR-positive B cell enhancer ABC_E5005 Neighboring gene RIKEN cDNA 5330439A09 gene Neighboring gene ankyrin repeat and SOCs box-containing 5 Neighboring gene predicted gene, 46039

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal peptide processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of signal peptidase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal peptidase complex subunit 3
    Names
    SPase 22/23 kDa subunit
    microsomal signal peptidase 22/23 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029701.1NP_083977.1  signal peptidase complex subunit 3

      Status: VALIDATED

      Source sequence(s)
      AK007432, AK037878, BY012914, CO041079
      Consensus CDS
      CCDS57621.1
      UniProtKB/Swiss-Prot
      Q6ZWQ7, Q8C1D0
      Related
      ENSMUSP00000136527.2, ENSMUST00000067476.9
      Conserved Domains (1) summary
      pfam04573
      Location:4173
      SPC22; Signal peptidase subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      54973468..54983033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)