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    Ces4a carboxylesterase 4A [ Mus musculus (house mouse) ]

    Gene ID: 234677, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ces4aprovided by MGI
    Official Full Name
    carboxylesterase 4Aprovided by MGI
    Primary source
    MGI:MGI:2384581
    See related
    Ensembl:ENSMUSG00000060560 AllianceGenome:MGI:2384581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ces8
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Predicted to be located in extracellular region. Is expressed in exocrine gland; genitourinary system; skin; and thyroid gland. Orthologous to human CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Ces4a in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105858432..105876741)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105131800..105150109)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 3B Neighboring gene STARR-positive B cell enhancer ABC_E5035 Neighboring gene microtubule-associated protein, RP/EB family, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22521 Neighboring gene predicted gene, 51414 Neighboring gene STARR-positive B cell enhancer ABC_E1106 Neighboring gene predicted gene, 22063 Neighboring gene core binding factor beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General protein information

    Preferred Names
    carboxylesterase 4A
    Names
    carboxylesterase 8 (putative)
    NP_666325.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146213.2NP_666325.2  carboxylesterase 4A precursor

      See identical proteins and their annotated locations for NP_666325.2

      Status: VALIDATED

      Source sequence(s)
      AC164311, AK037191, AV235376
      Consensus CDS
      CCDS22591.2
      UniProtKB/Swiss-Prot
      G3XA24, Q8R0W5
      Related
      ENSMUSP00000125062.2, ENSMUST00000161289.2
      Conserved Domains (2) summary
      COG0657
      Location:128272
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30554
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105858432..105876741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)